Evidence map›Paper›PMID 32937839›Full record

ArticleJournal of clinical medicine2020

Effects of Smoking and Smoking Cessation on the Intestinal Microbiota.

Marcus G Sublette, Tzu-Wen L Cross, Claudia E Korcarz, Kristin M Hansen, Sofia M Murga-Garrido, Stanley L Hazen, Zeneng Wang, Madeline K Oguss, Federico E Rey, James H Stein

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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  10. How the Microbiome Drives Cardiovascular Disease.The Surgical clinics of North America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marcus G SubletteDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Tzu-Wen L CrossDepartment of Nutrition Science, Purdue University, West Lafayette, Indiana, 47907, USA.
Claudia E KorcarzDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Kristin M HansenDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Sofia M Murga-GarridoDepartment of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0003-4527-9407
Stanley L HazenDepartment of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.
Zeneng WangDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0002-6455-8228
Madeline K OgussDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Federico E ReyDepartment of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.
James H SteinDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.ORCID 0000-0002-2770-8223

Funding

Project 3: Microbiota generated aryl sulfates and secondary bile acids in cardiometabolic diseaseP01HL147823 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MICHAEL ANDREW FISCHBACH · 2019 to 2026
$17.0M
Gut Flora Metabolism of Dietary Phosphatidylcholine and CVDR01HL103866 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2023
$10.8M
AB/SCIEX QTrap 6500 Mass Spectrometer Metabolic profiling systemS10OD016346 · OD · CLEVELAND CLINIC LERNER COM-CWRU · PI DIDONATO, JOSEPH · 2014 to 2014
$600k
NHLBI NIH HHS P01 HL147823NHLBI NIH HHS R01 HL103866
6 · The paper itself

Abstract

We evaluated associations of smoking heaviness markers and the effects of smoking cessation on the intestinal microbiota and cardiovascular disease risk factors in current smokers undertaking a quit attempt. Participants were current smokers enrolled in a prospective randomized clinical trial of smoking cessation therapies with visits at baseline, 2, and 12 weeks. Genomic DNA was extracted from fecal samples followed by 16S rRNA gene sequencing and analysis using the QIIME2 software workflow. Relative abundances of bacterial taxa and alpha- and beta-diversity measures were used for comparisons. The 36 smokers were (mean (standard deviation)) 51.5 (11.1) years old (42% male) and smoked 15.1 (6.4) cigarettes per day for 22.7 (11.9) pack-years. Relative abundances of the phylum Actinobacteria correlated with pack-years (rho = -0.44,

Indexed as

cardiovascular diseasegut floramicrobiomesmokingsmoking cessation

Identifiers

PMID32937839
PMCPMC7564179

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.