Evidence map›Paper›PMID 32937819›Full record

ArticleInternational journal of molecular sciences2020

Analyzing Gene Expression Profiles from Ataxia and Spasticity Phenotypes to Reveal Spastic Ataxia Related Pathways.

Andrea C Kakouri, Christina Votsi, Marios Tomazou, George Minadakis, Evangelos Karatzas, Kyproula Christodoulou, George M Spyrou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. PathIN: an integrated tool for the visualization of pathway interaction networks.Computational and structural biotechnology journal · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Andrea C KakouriDepartment of Bioinformatics, The Cyprus Institute of Neurology and Genetics, Nicosia 2370, Cyprus.ORCID 0000-0003-2982-679X
Christina VotsiDepartment of Neurogenetics, The Cyprus Institute of Neurology and Genetics, Nicosia 2370, Cyprus.
Marios TomazouDepartment of Bioinformatics, The Cyprus Institute of Neurology and Genetics, Nicosia 2370, Cyprus.ORCID 0000-0002-0836-5579
George MinadakisDepartment of Bioinformatics, The Cyprus Institute of Neurology and Genetics, Nicosia 2370, Cyprus.
Evangelos KaratzasInstitute for Fundamental Biomedical Research, BSRC "Alexander Fleming", 16672 Vari, Greece.
Kyproula ChristodoulouDepartment of Neurogenetics, The Cyprus Institute of Neurology and Genetics, Nicosia 2370, Cyprus.ORCID 0000-0002-0622-7594
George M SpyrouDepartment of Bioinformatics, The Cyprus Institute of Neurology and Genetics, Nicosia 2370, Cyprus.ORCID 0000-0002-2470-3363
Cyprus Institute of Neurology and Genetics · CYAlexander Fleming Biomedical Sciences Research Center · GR

Funding

European Commission Research Executive Agency (REA) BIORISE 669026
6 · The paper itself

Abstract

Spastic ataxia (SA) is a group of rare neurodegenerative diseases, characterized by mixed features of generalized ataxia and spasticity. The pathogenetic mechanisms that drive the development of the majority of these diseases remain unclear, although a number of studies have highlighted the involvement of mitochondrial and lipid metabolism, as well as calcium signaling. Our group has previously published the

Indexed as

Calcium SignalingCarbohydrate MetabolismGlucosylceramidaseHumansIntellectual DisabilityLipid MetabolismMitogen-Activated Protein KinasesMuscle SpasticityOptic AtrophyPhenotypePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionSphingolipidsSpinocerebellar AtaxiasTranscriptomeGlucosylceramidaseMitogen-Activated Protein KinasesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSphingolipidsdifferential expressiongene expressionneurodegenerationpathwaypathway analysisspastic ataxiasphingolipid

Identifiers

PMID32937819
PMCPMC7555177
OpenAlexW3085392384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.