Evidence map›Paper›PMID 32937653›Full record

ArticleThe Journal of nutrition2020

Association of Serum 25-Hydroxyvitamin D Deficiency with Risk of Incidence of Disability in Basic Activities of Daily Living in Adults >50 Years of Age.

Mariane M Luiz, Roberta Máximo, Dayane C Oliveira, Paula C Ramírez, Aline F de Souza, Maicon L B Delinocente, Andrew Steptoe, Cesar de Oliveira, Tiago Alexandre

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Mariane M LuizPostgraduate Program in Physical Therapy, Federal University of São Carlos, São Carlos, Brazil.
Roberta MáximoPostgraduate Program in Physical Therapy, Federal University of São Carlos, São Carlos, Brazil.
Dayane C OliveiraPostgraduate Program in Physical Therapy, Federal University of São Carlos, São Carlos, Brazil.
Paula C RamírezPostgraduate Program in Physical Therapy, Federal University of São Carlos, São Carlos, Brazil.
Aline F de SouzaPostgraduate Program in Physical Therapy, Federal University of São Carlos, São Carlos, Brazil.
Maicon L B DelinocentePostgraduate Program in Gerontology, Federal University of São Carlos, São Carlos, Brazil.
Andrew SteptoeDepartment of Epidemiology and Public Health, University College London, London, United Kingdom.
Cesar de OliveiraDepartment of Epidemiology and Public Health, University College London, London, United Kingdom.
Tiago AlexandrePostgraduate Program in Physical Therapy, Federal University of São Carlos, São Carlos, Brazil.
Universidade Federal de São Carlos · BRUniversity College London · GBIndustrial University of Santander · CO

Funding

Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2M
NIA NIH HHS R01 AG017644
6 · The paper itself

Abstract

backgroundVitamin D deficiency compromises muscle function and is related to the etiology of several clinical conditions that can contribute to the development of disability. However, there are few epidemiological studies investigating the association between vitamin D deficiency and the incidence of disability.

objectivesWe aimed to assess whether vitamin D deficiency is associated with the incidence of disability in basic activities of daily living (BADL) and to verify whether there are sex differences in this association.

methodsA 4-y follow-up study was conducted involving individuals aged 50 y or older who participated in ELSA (English Longitudinal Study of Ageing). The sample consisted of 4814 participants free of disability at baseline according to the modified Katz Index. Vitamin D was assessed by serum 25-hydroxyvitamin D [25(OH)D] concentrations and the participants were classified as sufficient (>50 nmol/L), insufficient (>30 to ≤50 nmol/L), or deficient (≤30 nmol/L). Sociodemographic, behavioral, and clinical characteristics were also investigated. BADL were re-evaluated after 2 and 4 y of follow-up. The report of any difficulty to perform ≥1 BADL was considered as an incident case of disability. Poisson models stratified by sex and controlled for sociodemographic, behavioral, and clinical characteristics were carried out.

resultsAfter 4-y follow-up, deficient serum 25(OH)D was a risk factor for the incidence of BADL disability in both women (IRR: 1.53; 95% CI: 1.16, 2.03) and men (IRR: 1.44; 95% CI: 1.02, 2.02). However, insufficient serum 25(OH)D was not a risk factor for the incidence of BADL disability in either men or women.

conclusionsIndependently of sex, deficient serum 25(OH)D concentrations were associated with increased risk of incidence of BADL disability in adults >50 y old and should be an additional target of clinical strategies to prevent disability in these populations.

Indexed as

Activities of Daily LivingVitamin D DeficiencyAgedAged, 80 and overFemaleHumansMaleMiddle AgedRisk FactorsSeasonsVitamin D25-hydroxyvitamin DVitamin D25-hydroxyvitamin Dagingdisabilityincidencevitamin D

Identifiers

PMID32937653
PMCPMC7675030
OpenAlexW3087523256

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.