Evidence map›Paper›PMID 32937637›Full record

ArticleJournal of vascular research2020

Early Morphofunctional Changes in AngII-Infused Mice Contribute to Regional Onset of Aortic Aneurysm and Dissection.

Lydia Aslanidou, Bram Trachet, Linda Sasset, Goran Lovric, Nikolaos Stergiopulos, Annarita Di Lorenzo

Open access · hybridAbstract readNews
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Lydia AslanidouInstitute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Bram TrachetInstitute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Linda SassetDepartment of Pathology and Laboratory Medicine, Cardiovascular Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA.
Goran LovricCentre d'Imagerie BioMédicale, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Nikolaos StergiopulosInstitute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Annarita Di LorenzoDepartment of Pathology and Laboratory Medicine, Cardiovascular Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA, and2039@med.cornell.edu.
Cornell University · USÉcole Polytechnique Fédérale de Lausanne · CHGhent University · BEPaul Scherrer Institute · CH

Funding

Endothelial Sphingolipid Synthesis and Tissue Inflammatory ResponseR01HL126913 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DI LORENZO, ANNARITA · 2015 to 2023
$3.5M
A NOVEL ISCHEMIC STROKE MODEL TRIGGERED BY ENDOTHELIAL DYSFUNCTIONR21NS104512 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI DI LORENZO, ANNARITA · 2018 to 2019
$466k
NHLBI NIH HHS R01 HL126913NINDS NIH HHS R21 NS104512
6 · The paper itself

Abstract

Aortic aneurysms and dissections are silent and lethal conditions, whose pathogenesis remains incompletely understood. Although angiotensin II (AngII)-infused ApoE-/- mice have been widely used to study aortic aneurysm and dissection, early morphofunctional alterations preceding the onset of these conditions remain unknown. The goal of this study was to unveil early morphofunctional changes underlying the onset of aneurysm and dissection. At 3 days post-AngII infusion, suprarenal abdominal aorta presented significant volumetric dilatation and microstructural damage. Ex vivo assessment of vascular reactivity of the suprarenal dissection-prone aorta and its side branches, showed an endothelial and contractile dysfunctions that were severe in the suprarenal aorta, moderate distally, and absent in the side branches, mirroring the susceptibility to dissection of these different vascular segments. Early and specific morphofunctional changes of the suprarenal aorta may contribute to the regional onset of aortic aneurysm and dissection by exacerbating the biomechanical burden arising from its side branches.

Indexed as

Angiotensin IIVascular RemodelingAnimalsAorta, AbdominalAortic Aneurysm, AbdominalAortic DissectionAortographyComputed Tomography AngiographyDilatation, PathologicDisease Models, AnimalEndothelium, VascularMaleMice, Inbred C57BLMice, Knockout, ApoEMuscle, Smooth, VascularTime FactorsAngiotensin IIAngiotensin IIAortic aneurysmAortic dissectionSynchrotronVascular reactivity

Identifiers

PMID32937637
PMCPMC7666086
OpenAlexW3087607961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.