ArticleScience advances2020
Signal dynamics of midbrain dopamine neurons during economic decision-making in monkeys.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Dopamine Dynamics in the Nucleus Accumbens Reflect Confidence in Detecting the Occurrence and Nonoccurrence of Visual Signals in Perceptual Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Role of the primate ventral striatum as a neural hub bridging option valuation and action selection.Nature communications · 2026Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Sense of agency and decision making.Frontiers in psychology · 2026Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.bioRxiv : the preprint server for biology · 2025Article
- The representation of decision variables in orbitofrontal cortex is longitudinally stable.Cell reports · 2024Article
- Cracking and Packing Information about the Features of Expected Rewards in the Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distinct roles of the orbitofrontal cortex, ventral striatum, and dopamine neurons in counterfactual thinking of decision outcomes.Science advances · 2023Article
- Distinct forms of regret linked to resilience versus susceptibility to stress are regulated by region-specific CREB function in mice.Science advances · 2022Article
- Laser stimulation of the skin for quantitative study of decision-making and motivation.Cell reports methods · 2022Article
- Review
- Chemogenetic Disconnection between the Orbitofrontal Cortex and the Rostromedial Caudate Nucleus Disrupts Motivational Control of Goal-Directed Action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Is the core function of orbitofrontal cortex to signal values or make predictions?Current opinion in behavioral sciences · 2021Article
- Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia.Translational psychiatry · 2021Article
- Single-unit Recording in Awake Behaving Non-human Primates.Bio-protocol · 2021Article
- Tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment.eLife · 2021Article
- Event-Related Potentials During Decision-Making in a Mixed-Strategy Game.Frontiers in neuroscience · 2021Article
- Neural circuitry of information seeking.Current opinion in behavioral sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When we make economic choices, the brain first evaluates available options and then decides whether to choose them. Midbrain dopamine neurons are known to reinforce economic choices through their signal evoked by outcomes after decisions are made. However, although critical internal processing is executed while decisions are being made, little is known about the role of dopamine neurons during this period. We found that dopamine neurons exhibited dynamically changing signals related to the internal processing while rhesus monkeys were making decisions. These neurons encoded the value of an option immediately after it was offered and then gradually changed their activity to represent the animal's upcoming choice. Similar dynamics were observed in the orbitofrontal cortex, a center for economic decision-making, but the value-to-choice signal transition was completed earlier in dopamine neurons. Our findings suggest that dopamine neurons are a key component of the neural network that makes choices from values during ongoing decision-making processes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.