Evidence map›Paper›PMID 32937377›Full record

ArticleScience advances2020

Laser writing of nitrogen-doped silicon carbide for biological modulation.

Vishnu Nair, Jaeseok Yi, Dieter Isheim, Menahem Rotenberg, Lingyuan Meng, Fengyuan Shi, Xinqi Chen, Xiang Gao, Aleksander Prominski, Yuanwen Jiang and 4 more

Abstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Thickness-Gradient Liquid Metal Connectors for Seamless Electrophysiological Sensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  18. Nanoenabled Bioelectrical Modulation.Accounts of materials research · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vishnu NairDepartment of Chemistry, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-7321-1170
Jaeseok YiJames Franck Institute, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-0578-1059
Dieter IsheimNorthwestern University Center for Atom-Probe Tomography, Evanston, IL 60208, USA.ORCID 0000-0003-3310-8192
Menahem RotenbergJames Franck Institute, University of Chicago, Chicago, IL 60637, USA.
Lingyuan MengPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-1690-586X
Fengyuan ShiElectron Microscopy Core, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0001-9769-3824
Xinqi ChenKeck Interdisciplinary Surface Science Center, Northwestern University, Evanston, IL 60208, USA.
Xiang GaoJames Franck Institute, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-0699-0351
Aleksander ProminskiDepartment of Chemistry, University of Chicago, Chicago, IL 60637, USA.
Yuanwen JiangDepartment of Chemistry, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-2056-2639
Jiping YueBen May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA.
Charles T GallagherDepartment of Physics, University of Chicago, Chicago, IL 60637, USA.
David N SeidmanNorthwestern University Center for Atom-Probe Tomography, Evanston, IL 60208, USA.ORCID 0000-0001-5237-1151
Bozhi TianDepartment of Chemistry, University of Chicago, Chicago, IL 60637, USA. btian@uchicago.edu.ORCID 0000-0003-0593-0023

Funding

Silicon-based Injectable Micro-gels for Non-genetic and Wireless Modulation of Neurons, Cardiomyocytes and Neuromuscular SystemDP2NS101488 · NINDS · UNIVERSITY OF CHICAGO · PI TIAN, BOZHI · 2016 to 2016
$2.4M
NINDS NIH HHS DP2 NS101488
6 · The paper itself

Abstract

Conducting or semiconducting materials embedded in insulating polymeric substrates can be useful in biointerface applications; however, attainment of this composite configuration by direct chemical processes is challenging. Laser-assisted synthesis has evolved as a fast and inexpensive technique to prepare various materials, but its utility in the construction of biophysical tools or biomedical devices is less explored. Here, we use laser writing to convert portions of polydimethylsiloxane (PDMS) into nitrogen-doped cubic silicon carbide (3C-SiC). The dense 3C-SiC surface layer is connected to the PDMS matrix via a spongy graphite layer, facilitating electrochemical and photoelectrochemical activity. We demonstrate the fabrication of arbitrary two-dimensional (2D) SiC-based patterns in PDMS and freestanding 3D constructs. To establish the functionality of the laser-produced composite, we apply it as flexible electrodes for pacing isolated hearts and as photoelectrodes for local peroxide delivery to smooth muscle sheets.

Identifiers

PMID32937377
PMCPMC7442483

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.