ArticleScience advances2020
The motor cortex uses active suppression to sculpt movement.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed.
- Spinal cord stimulation modulates post-synaptic inhibition to improve arm neuromotor control after chronic stroke.Cell reports. Medicine · 2026Article
- Review
- Functional organization of the primary motor cortex in psychosis and the potential role of intereffector regions in psychomotor slowing.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Spinal cord stimulation modulates post-synaptic inhibition improving neuromotor control of arm movement in people with chronic hemiparesis post-stroke.medRxiv : the preprint server for health sciences · 2025Article
- Global Motor System Suppression as the Primary Mechanism of Human Action Stopping: Challenging the Pause-Then-Cancel Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Multiple cortical systems influence a single vibrissa muscle.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- An ANN models cortical-subcortical interaction during post-stroke recovery of finger dexterity.Journal of neural engineering · 2024Article
- Evolution, biomechanics, and neurobiology converge to explain selective finger motor control.Physiological reviews · 2024Review
- Preparatory activity and the expansive null-space.Nature reviews. Neuroscience · 2024Review
- The role of dorsal premotor cortex in joint action inhibition.Scientific reports · 2024Article
- A Narrative Review of Stroke of Cortical Hand Knob Area.Medicina (Kaunas, Lithuania) · 2024Review
- Motor potentials evoked by transcranial magnetic stimulation: interpreting a simple measure of a complex system.The Journal of physiology · 2023Review
- Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys.Nature neuroscience · 2022Article
- Task-Related Modulation of Sensorimotor GABA+ Levels in Association with Brain Activity and Motor Performance: A Multimodal MRS-fMRI Study in Young and Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The role of dorsal premotor cortex in joint action stopping.iScience · 2021Article
- Neurons in Primary Motor Cortex Encode External Perturbations during an Orientation Reaching Task.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Even the simplest movements are generated by a remarkably complex pattern of muscle activity. Fast, accurate movements at a single joint are produced by a stereotyped pattern that includes a decrease in any preexisting activity in antagonist muscles. This premovement suppression is necessary to prevent the antagonist muscle from opposing movement generated by the agonist muscle. Here, we provide evidence that the primary motor cortex (M1) sends a command signal that generates this premovement suppression. Thus, output neurons in M1 sculpt complex spatiotemporal patterns of motor output not only by actively turning on muscles but also by actively turning them off.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.