ArticleScience advances2020
Competition between social cheater viruses is driven by mechanistically different cheating strategies.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
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Who cites it
18 citing papers in PubMed.
- Rethinking viral evolution: How BIAS mechanisms and Gamma-Poisson overdispersion redefine lethal mutagenesis.Frontiers in microbiology · 2026Article
- Navigating a Fine Balance: Point-Mutant Cheater Viruses Disrupt the Viral Replication Cycle.Molecular biology and evolution · 2025Article
- Mathematical model calibrated toiScience · 2024Article
- Shared sequence characteristics identified in non-canonical rearrangements of HSV-1 genomes.Journal of virology · 2023Article
- Open questions in the social lives of viruses.Journal of evolutionary biology · 2023Review
- Signatures of kin selection in a natural population of the bacteriaEvolution letters · 2023Article
- Equilibria and oscillations in cheat-cooperator dynamics.Evolution letters · 2023Article
- Article
- Cheating leads to the evolution of multipartite viruses.PLoS biology · 2023Article
- Mutation rate, selection, and epistasis inferred from RNA virus haplotypes via neural posterior estimation.Virus evolution · 2023Article
- The evolution of manipulative cheating.eLife · 2022Article
- Kin selection for cooperation in natural bacterial populations.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Interactions between bacterial and phage communities in natural environments.Nature reviews. Microbiology · 2022Review
- Segregational Drift Constrains the Evolutionary Rate of Prokaryotic Plasmids.Molecular biology and evolution · 2021Article
- Characterizing hydrogen bonds in intact RNA from MS2 bacteriophage using magic angle spinning NMR.Biophysical reports · 2021Article
- The evolution of cheating in viruses.Nature communications · 2021Review
- Article
- Ten recent insights for our understanding of cooperation.Nature ecology & evolution · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cheater viruses, also known as defective interfering viruses, cannot replicate on their own yet replicate faster than the wild type upon coinfection. While there is growing interest in using cheaters as antiviral therapeutics, the mechanisms underlying cheating have been rarely explored. During experimental evolution of MS2 phage, we observed the parallel emergence of two independent cheater mutants. The first, a point deletion mutant, lacked polymerase activity but was advantageous in viral packaging. The second synonymous mutant cheater displayed a completely different cheating mechanism, involving an altered RNA structure. Continued evolution revealed the demise of the deletion cheater and rise of the synonymous cheater. A mathematical model inferred that while a single cheater is expected to reach an equilibrium with the wild type, cheater demise arises from antagonistic interactions between coinfecting cheaters. These findings highlight layers of parasitism: viruses parasitizing cells, cheaters parasitizing intact viruses, and cheaters may parasitize other cheaters.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.