Evidence map›Paper›PMID 32937126›Full record

ArticleCell reports2020

Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant.

Oswaldo A Lozoya, Fuhua Xu, Dagoberto Grenet, Tianyuan Wang, Sara A Grimm, Veronica Godfrey, Suramya Waidyanatha, Richard P Woychik, Janine H Santos

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Progeny effects of rotenone exposure depend on parental toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Low-Dose Non-Targeted Effects and Mitochondrial Control.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Observational
  13. Mitochondrial signal transduction.Cell metabolism · 2022
    Review
  14. Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stress.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  15. Article
  16. Article
  17. Mitochondrial DNA damage as driver of cellular outcomes.American journal of physiology. Cell physiology · 2022
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Oswaldo A LozoyaGenome Integrity and Structural Biology Laboratory, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Fuhua XuGenome Integrity and Structural Biology Laboratory, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Dagoberto GrenetGenome Integrity and Structural Biology Laboratory, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Tianyuan WangIntegrative Bioinformatics Support Group, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Sara A GrimmIntegrative Bioinformatics Support Group, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Veronica GodfreyNational Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Suramya WaidyanathaNational Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Richard P WoychikGenome Integrity and Structural Biology Laboratory, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address: rick.woychik@nih.gov.
Janine H SantosGenome Integrity and Structural Biology Laboratory, National Institutes of Health, Research Triangle Park, NC 27709, USA; National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address: janine.santos@nih.gov.
National Institutes of Health · US

Funding

Role of environmental agents targeting mitochondria in epigenetic regulation of nuclear gene expressionZIAES103186 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WOYCHIK, RICHARD · 2014 to 2020
$4.9M
Intramural NIH HHS ZIA ES103186
6 · The paper itself

Abstract

Mitochondrial-driven alterations of the epigenome have been reported, but whether they are relevant at the organismal level remains unknown. The viable yellow agouti mouse (A

Indexed as

AnimalsDNA MethylationDNA, MitochondrialEpigenesis, GeneticEpigenomicsFemaleGene ExpressionGene Expression RegulationMaternal ExposureMiceMice, Inbred C57BLMitochondriaNucleotidesRotenoneDNA, MitochondrialNucleotidesRotenonecomplex Idevelopmental exposureDNA methylationepigeneticsgene expressionmitochondriatoxicant

Identifiers

PMID32937126
PMCPMC7553240
OpenAlexW3084788160

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.