ArticleBiophysical journal2021
Sequence effects on internal structure of droplets of associative polymers.
Article in Biophysical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Role of Charge Patterning and Hydrophobicity in Peptide-Based Complex Coacervates.Biomacromolecules · 2025Article
- Phase Transitions of Associative Biomacromolecules.Chemical reviews · 2023Review
- Biophysics of biomolecular condensates.Biophysical journal · 2023Article
- The Regulatory Roles of Intrinsically Disordered Linker in VRN1-DNA Phase Separation.International journal of molecular sciences · 2022Article
- Faces, facets, and functions of biomolecular condensates driven by multivalent proteins and nucleic acids.Biophysical journal · 2021Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Intrinsically disordered proteins (IDPs) can form liquid-like membraneless organelles, gels, and fibers in cells and in vitro. In this study, we propose a simple model of IDPs as associative polymers in poor solvent and explore the formation of transient liquid droplets and their transformation into solid-like aggregates. We use Langevin dynamics simulations of short polymers with two stickers placed symmetrically along their contour to study the effect of the primary sequence of these polymers on their organization inside condensed droplets. We observe that the shape, size, and number of sticker clusters inside the droplet change from a long cylindrical fiber to many compact clusters as one varies the location of stickers along the chain contour. Aging caused by the conversion of intramoleclular to intermolecular associations is observed in droplets of telechelic polymers but not for other sequences of associating polymers. The relevance of our results to condensates of IDPs is discussed.
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