Evidence map›Paper›PMID 32937101›Full record

ArticleStructure (London, England : 1993)2021

Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase.

Steven E Cohen, Edward J Brignole, Elizabeth C Wittenborn, Mehmet Can, Samuel Thompson, Stephen W Ragsdale, Catherine L Drennan

Open access · bronzeAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Capturing a methanogenic carbon monoxide dehydrogenase/acetyl-CoA synthase complex via cryogenic electron microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Review
  6. Review
  7. Thioester synthesis by a designed nickel enzyme models prebiotic energy conversion.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Steven E CohenDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Edward J BrignoleDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Elizabeth C WittenbornDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Mehmet CanDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Samuel ThompsonDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Stephen W RagsdaleDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Catherine L DrennanDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Fellow, Bio-inspired Solar Energy Program, Canadian Institute for Advanced Research (CIFAR), Toronto, ON M5G 1M1. Electronic address: cdrennan@mit.edu.
Massachusetts Institute of Technology · USUniversity of Michigan · USCanadian Institute for Advanced Research · CA

Funding

Interdepartmental Biotechnology Training ProgramT32GM008334 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WITTRUP, KARL DANE · 1989 to 2018
$15.2M
Enzymology of the Reductive Acetyl-CoA PathwayR37GM039451 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAGSDALE, STEPHEN WILEY · 2012 to 2021
$4.0M
Metalloenzyme structure, function and assemblyR35GM126982 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CATHERINE L DRENNAN · 2018 to 2026
$3.4M
Complex Metallocluster Structure and AssemblyR01GM069857 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DRENNAN, CATHERINE L · 2004 to 2017
$3.1M
Metalloprotein Mechanisms of Redox Regulation and CatalysisR35GM141758 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAGSDALE, STEPHEN WILEY · 2021 to 2025
$3.0M
NIGMS NIH HHS R01 GM069857NIGMS NIH HHS R35 GM126982NIGMS NIH HHS R35 GM141758NIGMS NIH HHS R37 GM039451NIGMS NIH HHS T32 GM008334
6 · The paper itself

Abstract

The Ni-Fe-S-containing A-cluster of acetyl-coenzyme A (CoA) synthase (ACS) assembles acetyl-CoA from carbon monoxide (CO), a methyl group (CH

Indexed as

Aldehyde OxidoreductasesBacterial ProteinsIronMolecular Dynamics SimulationMoorellaMultienzyme ComplexesNickelProtein DomainsSulfurAldehyde OxidoreductasesBacterial Proteinscarbon monoxide dehydrogenaseIronMultienzyme ComplexesNickelSulfuracetogenesisacetyl-CoA synthasecarbon dioxide sequestrationcarbon fixationCO dehydrogenaseelectron microscopymetalloenzymemethyl transferprotein dynamicsWood-Ljungdahl

Identifiers

PMID32937101
PMCPMC7796957
OpenAlexW3086503530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.