SynthesisHuman brain mapping2020
Shaky scaffolding: Age differences in cerebellar activation revealed through activation likelihood estimation meta-analysis.
Synthesis in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Consistent cortico-basal ganglia-cerebellar activation in early motor sequence learning: a systematic review and meta-analysis.Translational psychiatry · 2026Pooled it
- Differential vulnerability of the cerebellum in healthy ageing and Alzheimer's disease.NeuroImage. Clinical · 2021Pooled it
- Shaky scaffolding: Age differences in cerebellar activation revealed through activation likelihood estimation meta-analysis.Human brain mapping · 2020Pooled it
- Multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults.Scientific reports · 2021Trial
- Cerebellar Network Compensation in Parkinson's Disease: Functional Connectivity Across Motor and Cognitive Circuits.medRxiv : the preprint server for health sciences · 2026Article
- Age-Related Low Frequency Amplitude Differences in Resting-State Blood Oxygenation Level-Dependent Signal in the Cerebellum.Human brain mapping · 2026Article
- Age-related cerebello-thalamo-cortical white matter degradation and executive function performance across the lifespan.Scientific reports · 2026Article
- Seeing and deciding to help: neural and attentional mechanisms of prosociality in younger and older adults.Social cognitive and affective neuroscience · 2026Article
- Brain Functional and Structural Changes of Breast Cancer After Chemotherapy: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Review
- The Influence of Sex and Sex-Steroid Hormones on Cerebellar Structure and Functional Connectivity Across Adulthood.Human brain mapping · 2025Article
- Glial Cells and Aging: From the CNS to the Cerebellum.International journal of molecular sciences · 2025Review
- Alzheimer's disease cerebrospinal fluid biomarker levels and APOE genetic status are associated with hippocampal-cerebellar functional connectivity.Neurobiology of aging · 2025Article
- Aging Impacts Basic Auditory and Timing Processes.The European journal of neuroscience · 2025Article
- Time Dependent Effects of Cerebellar tDCS on Cerebello-cortical Connectivity Networks in Young Adults.Cerebellum (London, England) · 2025Article
- Functional and structural cerebellar-behavior relationships in aging.Brain structure & function · 2024Article
- Cerebello-Hippocampal Interactions in the Human Brain: A New Pathway for Insights Into Aging.Cerebellum (London, England) · 2024Review
- Non-invasive neuromodulation of cerebello-hippocampal volume-behavior relationships.bioRxiv : the preprint server for biology · 2024Article
- Consensus Paper: Cerebellum and Ageing.Cerebellum (London, England) · 2024Review
- New Frontiers for the Understanding of Aging: The Power and Possibilities of Studying the Cerebellum.Current opinion in behavioral sciences · 2023Article
- Cerebello-basal Ganglia Networks and Cortical Network Global Efficiency.Cerebellum (London, England) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Cognitive neuroscience research has provided foundational insights into aging, but has focused primarily on the cerebral cortex. However, the cerebellum is subject to the effects of aging. Given the importance of this structure in the performance of motor and cognitive tasks, cerebellar differences stand to provide critical insights into age differences in behavior. However, our understanding of cerebellar functional activation in aging is limited. Thus, we completed a meta-analysis of neuroimaging studies across task domains. Unlike in the cortex where an increase in bilateral activation is seen during cognitive task performance with advanced age, there is less overlap in cerebellar activation across tasks in older adults (OAs) relative to young. Conversely, we see an increase in activation overlap in OAs during motor tasks. We propose that this is due to inputs for comparator processing in the context of control theory (cortical and spinal) that may be differentially impacted in aging. These findings advance our understanding of the aging mind and brain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.