ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Subclinical Tuberculosis Disease-A Review and Analysis of Prevalence Surveys to Inform Definitions, Burden, Associations, and Screening Methodology.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07517471 (Start4All - Start Taking Action for TB Diagnosis SCREEN-TB), which is not on this map. Cited by 200 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Start4All - Start Taking Action for TB Diagnosis SCREEN-TB
Who cites it
200 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The asymptomatic tuberculosis proportion among the elderly population: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Subclinical tuberculosis: a meta-analysis of prevalence and scoping review of definitions, prevalence and clinical characteristics.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Yield and Efficiency of a Population-Based Mass Tuberculosis Screening Intervention Among Persons With Diabetes in Jiangsu Province, China.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Pooled it
- Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin.The Cochrane database of systematic reviews · 2022Pooled it
- Community-based active case-finding interventions for tuberculosis: a systematic review.The Lancet. Public health · 2021Pooled it
- Xpert MTB/RIF and Xpert Ultra assays for screening for pulmonary tuberculosis and rifampicin resistance in adults, irrespective of signs or symptoms.The Cochrane database of systematic reviews · 2021Pooled it
- Household Contact Tracing With Intensified Tuberculosis and Human Immunodeficiency Virus Screening in South Africa: A Cluster-Randomized Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial.The Lancet. Infectious diseases · 2021Trial
- Tuberculosis disease and infection among household contacts of bacteriologically confirmed vs unconfirmed tuberculosis in Cambodia: considerations for optimising contact investigation and preventive treatment.Annals of medicine · 2026Article
- Estimating the contribution to transmission of asymptomatic tuberculosis from population-based genomic epidemiology studies.Emerging microbes & infections · 2026Article
- Tuberculosis disease and infection screening among migrants in the Netherlands 2019-2023: a national retrospective observational study.The Lancet regional health. Europe · 2026Article
- Article
- High Initiation but Suboptimal Completion of Tuberculosis-Preventive Treatment Among People Living With HIV on Antiretroviral Therapy, Persistent Tuberculosis Incidence, and Programmatic Implications: Findings From a 2-Year Multicountry Cohort Study.Open forum infectious diseases · 2026Article
- Active screening for asymptomatic versus symptomatic tuberculosis in high-risk groups in a low-prevalence country: a retrospective study.Infection · 2026Article
- Lung Resident T Cells Across the Spectrum of TB Infection and Disease.bioRxiv : the preprint server for biology · 2026Article
- Centralized molecular testing of community-collected tongue swabs for tuberculosis screening among household contacts: a cross-sectional diagnostic performance, yield, and implementation study.medRxiv : the preprint server for health sciences · 2026Article
- Inflammatory biomarkers of asymptomatic and symptomatic tuberculosis.Nature communications · 2026Article
- Asymptomatic Tuberculosis: The Silent Face of the Disease Among Migrants and Refugees and the Challenges in Brazil.Journal of immigrant and minority health · 2026Article
- Treatment outcomes and risk factors for unfavorable results among older asymptomatic pulmonary tuberculosis patients in China, 2021-2024.BMC geriatrics · 2026Article
- A public-private partnership for facility-based tuberculosis screening using chest radiographs, Viet Nam.Bulletin of the World Health Organization · 2026Article
140 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
While it is known that a substantial proportion of individuals with tuberculosis disease (TB) present subclinically, usually defined as bacteriologically-confirmed but negative on symptom screening, considerable knowledge gaps remain. Our aim was to review data from TB prevalence population surveys and generate a consistent definition and framework for subclinical TB, enabling us to estimate the proportion of TB that is subclinical, explore associations with overall burden and program indicators, and evaluate the performance of screening strategies. We extracted data from all publicly available prevalence surveys conducted since 1990. Between 36.1% and 79.7% (median, 50.4%) of prevalent bacteriologically confirmed TB was subclinical. No association was found between prevalence of subclinical and all bacteriologically confirmed TB, patient diagnostic rate, or country-level HIV prevalence (P values, .32, .4, and .34, respectively). Chest Xray detected 89% (range, 73%-98%) of bacteriologically confirmed TB, highlighting the potential of optimizing current TB case-finding policies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.