ArticlePloS one2020
Most frequent South Asian haplotypes of ACE2 share identity by descent with East Eurasian populations.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Polymorphisms and mutations of ACE2 and TMPRSS2 genes are associated with COVID-19: a systematic review.European journal of medical research · 2022Pooled it
- Cycle Threshold (Ct) Value Trends in COVID-19: Analyzing Gender, Age, and Severity Factors Across Major Waves in India.Immunity, inflammation and disease · 2026Article
- The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury.Advances in virology · 2025Review
- Article
- The immunogenetics of COVID-19.Immunogenetics · 2023Review
- Genetic Variants within SARS-CoV-2 Human Receptor Genes May Contribute to Variable Disease Outcomes in Different Ethnicities.International journal of molecular sciences · 2023Review
- Estimation of real COVID-19 cases in India during the first wave.IJID regions · 2023Article
- Genetic Variations in the Human Angiotensin-ConvertingEnzyme 2 and Susceptibility to Coronavirus Disease-19.Genetics research · 2023Article
- Association investigations between ACE1 and ACE2 polymorphisms and severity of COVID-19 disease.Molecular genetics and genomics : MGG · 2023Article
- Lineage-specific positive selection onNational science review · 2022Article
- Review
- Article
- COVID-19: Impact on linguistic and genetic isolates of India.Genes and immunity · 2022Article
- Host polymorphisms and COVID-19 infection.Advances in clinical chemistry · 2022Article
- Triple jeopardy in ageing: COVID-19, co-morbidities and inflamm-ageing.Ageing research reviews · 2022Review
- Features and applications of haplotypes in crop breeding.Communications biology · 2021Review
- SARS-CoV-2 transgressing LncRNAs uncovers the known unknowns.Physiological genomics · 2021Article
- Genomic and Ancestral Variation Underlies the Severity of COVID-19 Clinical Manifestation in Individuals of European Descent.Life (Basel, Switzerland) · 2021Article
- The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations.Scientific reports · 2021Article
- COVID-19: The Cause of the Manifested Cardiovascular Complications During the Pandemic.Frontiers in cardiovascular medicine · 2021Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It was shown that the human Angiotensin-converting enzyme 2 (ACE2) is the receptor of recent coronavirus SARS-CoV-2, and variation in this gene may affect the susceptibility of a population. Therefore, we have analysed the sequence data of ACE2 among 393 samples worldwide, focusing on South Asia. Genetically, South Asians are more related to West Eurasian populations rather than to East Eurasians. In the present analyses of ACE2, we observed that the majority of South Asian haplotypes are closer to East Eurasians rather than to West Eurasians. The phylogenetic analysis suggested that the South Asian haplotypes shared with East Eurasians involved two unique event polymorphisms (rs4646120 and rs2285666). In contrast with the European/American populations, both of the SNPs have largely similar frequencies for East Eurasians and South Asians, Therefore, it is likely that among the South Asians, host susceptibility to the novel coronavirus SARS-CoV-2 will be more similar to that of East Eurasians rather than to that of Europeans.
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Registered trials
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