Evidence map›Paper›PMID 32936826›Full record

ArticlePloS one2020

Isolation and characterization of severe acute respiratory syndrome coronavirus 2 in Turkey.

Shaikh Terkis Islam Pavel, Hazel Yetiskin, Gunsu Aydin, Can Holyavkin, Muhammet Ali Uygut, Zehra Bestepe Dursun, İlhami Celik, Ceren Cevik, Aykut Ozdarendeli

3 registry-linked trialsOpen access · goldAbstract readComparative Study
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04942405 phase3completednot on this mapstarted 2021, after this paper: background citation

Efficacy, Immunogenicity, and Safety of the Two-Dose Inactivated COVID-19 Vaccine (TURKOVAC) Versus the Two-Dose CoronaVac (Sinovac) Vaccine in Healthy Subjects: A Randomized, Observer-Blinded, Phase III Clinical Trial

TypeinterventionalSponsorHealth Institutes of TurkeyRan2021 to 2024Enrolled1,290ConditionsCovid19ArmsTURCOVAC, CoronaVac
NCT05077176 phase3completednot on this mapstarted 2021, after this paper: background citation

Open Label, Multi-Center Phase 3 Clinical Trial to Determine Safety, Efficacy, and Immunogenicity of Booster Vaccination Against SARS-CoV-2

TypeinterventionalSponsorHealth Institutes of TurkeyRan2021 to 2024Enrolled4,340ConditionsCOVID-19, Sars-CoV-2 InfectionArmsCoronaVac, Turkovac
NCT06997653 phase2withdrawnnot on this mapstarted 2024, after this paper: background citation

Open-Label, Phase 2b Clinical Trial to Determine Efficacy, Safety, and Immunogenicity of Inactivated COVID-19 Vaccine (TURKOVAC) Against SARS-CoV-2 in Healthy Pregnant Women

TypeinterventionalSponsorHealth Institutes of TurkeyRan2024 to 2024Enrolled0ConditionsCOVID-19, SARS CoV 2 InfectionArmsTURKOVAC
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shaikh Terkis Islam PavelDepartment of Microbiology, Medical Faculty, Erciyes University, Kayseri, Turkey.
Hazel YetiskinDepartment of Microbiology, Medical Faculty, Erciyes University, Kayseri, Turkey.
Gunsu AydinDepartment of Microbiology, Medical Faculty, Erciyes University, Kayseri, Turkey.
Can HolyavkinGen Era Diagnostics Inc. Barbaros, Istanbul, Turkey.ORCID 0000-0003-4911-9494
Muhammet Ali UygutVaccine Research, Development and Application Center, Erciyes University, Kayseri, Turkey.
Zehra Bestepe DursunDepartment of Microbiology and Infectious Disease, Kayseri City Training and Research Hospital, Kayseri, Turkey.
İlhami CelikDepartment of Microbiology and Infectious Disease, Kayseri City Training and Research Hospital, Kayseri, Turkey.ORCID 0000-0002-2604-3776
Ceren CevikGen Era Diagnostics Inc. Barbaros, Istanbul, Turkey.
Aykut OzdarendeliDepartment of Microbiology, Medical Faculty, Erciyes University, Kayseri, Turkey.ORCID 0000-0002-6950-8545
Erciyes University · TRKayseri Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and associated with severe respiratory illness emerged in Wuhan, China, in late 2019. The virus has been able to spread promptly across all continents in the world. The current pandemic has posed a great threat to public health concern and safety. Currently, there are no specific treatments or licensed vaccines available for COVID-19. We isolated SARS-CoV-2 from the nasopharyngeal sample of a patient in Turkey with confirmed COVID-19. We determined that the Vero E6 and MA-104 cell lines are suitable for supporting SARS-CoV-2 that supports viral replication, development of cytopathic effect (CPE) and subsequent cell death. Phylogenetic analyses of the whole genome sequences showed that the hCoV-19/Turkey/ERAGEM-001/2020 strain clustered with the strains primarily from Australia, Canada, England, Iran and Kuwait and that the cases in the nearby clusters were reported to have travel history to Iran and to share the common unique nucleotide substitutions.

Indexed as

PandemicsAnimalsAustraliaBetacoronavirusCanadaCell LineChlorocebus aethiopsContact TracingCoronavirus InfectionsCOVID-19Cytopathogenic Effect, ViralDNA, ComplementaryDNA, ViralEnglandGenome, ViralHeLa CellsDNA, ComplementaryDNA, Viral

Identifiers

PMID32936826
PMCPMC7494126
OpenAlexW3084763251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.