ArticleAmerican journal of physiology. Cell physiology2020
Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function.
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Article in American journal of physiology. Cell physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed.
- Role of Copper Homeostasis and Cuproptosis in Cardiovascular Disease: Molecular Insights and Metabolic Perspectives.International journal of biological sciences · 2026Review
- Ferroptosis and cuproptosis in head and neck squamous cell carcinoma: interconnected mechanisms and therapeutic implications.Frontiers in pharmacology · 2026Review
- Mild traumatic brain injury promotes chronic cerebrovascular inflammation and glymphatic suppression.Molecular neurodegeneration advances · 2026Article
- Therapeutic targeting of post-translational modifications in ovarian cancer: mechanisms and clinical applications.Journal of ovarian research · 2025Review
- Caveolin-1 negatively regulates the calcitonin receptor-like receptor and neuroinflammation in a female mouse model of migraine.Journal of neuroinflammation · 2025Article
- The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer.Signal transduction and targeted therapy · 2025Review
- Caveolin and oxidative stress in cardiac pathology.Frontiers in physiology · 2025Review
- Yttrium Oxide Nanoparticles Affect Both Cognitive and Memory Function by Disrupting Copper Output in Neuronal Cells in a Rat Model.International journal of nanomedicine · 2025Article
- Heavy metal pollution and ischemic stroke: multimechanistic pathogenesis and countermeasures.Frontiers in public health · 2025Review
- The ion transport, GPCR, and RTK toolkit expression in the human cerebrovascular endothelial cell line, hCMEC/D3: an Omics perspective.Frontiers in physiology · 2025Article
- The critical roles of caveolin-1 in lung diseases.Frontiers in pharmacology · 2024Review
- Role of copper and its complexes in cardiovascular diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Elesclomol, a copper-transporting therapeutic agent targeting mitochondria: from discovery to its novel applications.Journal of translational medicine · 2023Review
- Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease.Journal of translational medicine · 2023Review
- Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy.Molecules (Basel, Switzerland) · 2023Review
- Preparation of Ultra-Small Copper Nanoparticles-Loaded Self-Healing Hydrogels with Antibacterial, Inflammation-Suppressing and Angiogenesis-Enhancing Properties for Promoting Diabetic Wound Healing.International journal of nanomedicine · 2023Article
- Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A.Molecular oncology · 2021Article
- Dipeptidyl peptidase-4 inhibition prevents lung injury in mice under chronic stress via the modulation of oxidative stress and inflammation.Experimental animals · 2021Article
- Sex Dimorphism in Pulmonary Hypertension: The Role of the Sex Chromosomes.Antioxidants (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Varadarajan SudhaharVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia.
Mustafa Nazir OkurLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
John P O'BryanDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Richard D MinshallDepartments of Anesthesiology and Pharmacology, University of Illinois at Chicago, Chicago, Illinois.
David FultonVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia.
Masuko Ushio-FukaiVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia.
Tohru FukaiVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia.
Funding
The role of SMAD1 and SATB2 in colon patterningP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Hailong Zhang · 2020 to 2026
$18.7MImpact of dyslipidemia on endothelial biomechanicsR01HL083298 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEVITAN, IRENA, MINSHALL, RICHARD D · 2007 to 2021
$7.0MVascular Extracellular Superoxide Dismutase ModulationR01HL070187 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FUKAI, TOHRU · 2002 to 2017
$4.2MNew Strategies for Treating Septic Vasculopathy Inflammation and ThrombosisR01HL125356 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BONINI, MARCELO G., DU, XIAOPING · 2014 to 2018
$3.4MRedox Regulation of Cu Importer CTR1 in AngiogenesisR01HL147550 · NHLBI · AUGUSTA UNIVERSITY · PI FUKAI, TOHRU, USHIO-FUKAI, MASUKO · 2020 to 2023
$3.3MCopper transport protein and inflammatory angiogenesisR01HL116976 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FUKAI, TOHRU, USHIO-FUKAI, MASUKO · 2013 to 2016
$2.9MCu Transporting ATPase and Diabetic Vascular ComplicationsR01HL133613 · NHLBI · AUGUSTA UNIVERSITY · PI FUKAI, TOHRU, USHIO-FUKAI, MASUKO · 2017 to 2020
$2.7MReactive Oxygen Species and Endothelial MigrationR01HL077524 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI USHIO-FUKAI, MASUKO · 2006 to 2010
$2.2MFibroblast Mediated Mechanisms of Pulmonary HypertensionR01HL142636 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MINSHALL, RICHARD D · 2019 to 2023
$2.0MProtein Disulfide Isomerase as Novel Redox Sensor in VEGF SignalingR01HL135584 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI USHIO-FUKAI, MASUKO · 2017 to 2020
$1.5MRole of Cysteine Sulfenic Acid Formation in Compartmentalization of VEGF SignalinR21HL112293 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI USHIO-FUKAI, MASUKO · 2013 to 2014
$435kSUMOylation of Cu transport protein Atox1 in AtherosclerosisI01BX001232 · VA · JESSE BROWN VA MEDICAL CENTER · PI TOHRU FUKAI · 2012 to 2026
–BLRD VA I01 BX001232NHLBI NIH HHS R01 HL070187NHLBI NIH HHS R01 HL077524NHLBI NIH HHS R01 HL083298NHLBI NIH HHS R01 HL116976NHLBI NIH HHS R01 HL125356NHLBI NIH HHS R01 HL133613NHLBI NIH HHS R01 HL135584NHLBI NIH HHS R01 HL142636NHLBI NIH HHS R01 HL147550NHLBI NIH HHS R21 HL112293NIGMS NIH HHS P20 GM130457
Abstract
Caveolin-1 (Cav-1) is a scaffolding protein and a major component of caveolae/lipid rafts. Previous reports have shown that endothelial dysfunction in Cav-1-deficient (Cav-1
Indexed as
AnimalsAortaCaveolin 1CopperCopper-Transporting ATPasesCopper Transport ProteinsEndothelial CellsFibroblastsGene Expression RegulationMaleMesenteric ArteriesMiceMice, Inbred C57BLMice, KnockoutMolecular ChaperonesOxidative StressAtox1 protein, mouseAtp7a protein, mouseCav1 protein, mouseCaveolin 1CopperCopper-Transporting ATPasesCopper Transport Proteinscupric chlorideMolecular ChaperonesProteasome Endopeptidase ComplexSod1 protein, mouseSod3 protein, mouseSuperoxide DismutaseSuperoxide Dismutase-1ATP7Acaveolin-1endothelial functionoxidative stressSOD3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.