Evidence map›Paper›PMID 32936489›Full record

ArticleMagnetic resonance in medicine2021

Feasibility of QSM in the human placenta.

Zungho Zun, Kushal Kapse, Jessica Quistorff, Nickie Andescavage, Alexis C Gimovsky, Homa Ahmadzia, Catherine Limperopoulos

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Observational
  3. Contrast-Invariant Self-supervised Segmentation for Quantitative Placental MRI.Perinatal, preterm and paediatric image analysis (2025) · 2026
    Article
  4. Advancements in MRI application in the morphological development of fetal cerebral venous system: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. QSM Throughout the Body.Journal of magnetic resonance imaging : JMRI · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zungho ZunDeveloping Brain Institute, Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, USA.ORCID 0000-0002-7297-3990
Kushal KapseDeveloping Brain Institute, Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, USA.
Jessica QuistorffDeveloping Brain Institute, Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, USA.
Nickie AndescavageDepartment of Pediatrics, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
Alexis C GimovskyDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
Homa AhmadziaDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
Catherine LimperopoulosDeveloping Brain Institute, Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, USA.

Funding

Clinical and Translational Science Institute at Children's NationalUL1TR000075 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2012 to 2015
$13.7M
Antecedents of Impaired Brain Development in Fetuses with Heart DiseaseR01HL116585 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI LIMPEROPOULOS, CATHERINE · 2013 to 2017
$3.8M
Assessment of placental perfusion and oxygenation using novel MRI approaches.R01HD100012 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZUN, ZUNGHO · 2019 to 2022
$2.4M
Clinical and Translational Science Institute at Children's NationalKL2TR000076 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2012 to 2014
$756k
NCATS NIH HHS KL2 TR000076NCATS NIH HHS UL1 TR000075NHLBI NIH HHS R01 HL116585NICHD NIH HHS R01 HD100012
6 · The paper itself

Abstract

purposeQuantitative susceptibility mapping (QSM) is an emerging tool for the precise characterization of human tissue, including regional oxygenation. A critical function of the human placenta is oxygen transfer to the developing fetus, which remains difficult to study in utero. The purpose of this study is to investigate the feasibility of performing QSM in the human placenta in utero.

methodsIn healthy pregnant women, 3D gradient echo data of the placenta were acquired with prospective respiratory gating at 1.5 Tesla and 3 Tesla. A brief period (6-7 min) of maternal hyperoxia was induced to increase placental oxygenation in a subset of women scanned at 3 Tesla, and data were acquired before and during oxygen administration. Susceptibility and

resultsA total of 54 women were studied at a mean gestational age of 30.7 ± 4.2 (range: 24 5/7-38 4/7) weeks. Susceptibility and

conclusionThis study demonstrates the feasibility of performing placental QSM in pregnant women and supports the potential for placental QSM to provide noninvasive in vivo assessment of placental oxygenation.

Indexed as

HyperoxiaMagnetic Resonance ImagingFeasibility StudiesFemaleHumansInfantPlacentaPregnancyProspective StudiesplacentaQSMquantitative susceptibility mapping

Identifiers

PMID32936489
PMCPMC12502593

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.