Observational studyClinical cardiology2020
Effect of obstructive sleep apnea on right ventricular ejection fraction in patients with hypertrophic obstructive cardiomyopathy.
Observational study in Clinical cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Obstructive Sleep Apnea Is Associated with Increased Myocardial Scar Burden in Patients with Obstructive Hypertrophic Cardiomyopathy.CJC open · 2026Article
- Prevalence and Clinical Implications of Sleep Apnea in Hypertrophic Cardiomyopathy.JAMA cardiology · 2025Article
- The role of cardiac magnetic resonance imaging in obstructive sleep apnea: a systematic scoping review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Acute sleep deprivation: impairment of biventricular function assesed by speckle tracking echocardiography in healthy subjects.Sleep & breathing = Schlaf & Atmung · 2023Article
- The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study.Frontiers in genetics · 2023Article
- Obstructive Sleep Apnea and Sleep Structure Assessed in Polysomnography and Right Ventricular Strain Parameters.Brain sciences · 2022Article
- Effect of obstructive sleep apnea on right ventricular ejection fraction in patients with hypertrophic obstructive cardiomyopathy.Clinical cardiology · 2020Observational
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundObstructive sleep apnea (OSA) is a common disease associated with worse structural and functional impairment of the heart in patients with hypertrophic obstructive cardiomyopathy (HOCM). HYPOTHESIS: The presence and severity of OSA can decrease the right ventricular ejection fraction (RVEF) in patients with HOCM.
methodsIn total, 151 consecutive patients with a confirmed diagnosis of HOCM at Fuwai Hospital between September 2017 and September 2018 were included. Polysomnography and cardiac magnetic resonance imaging were performed in all patients.
resultsOverall, 84 (55.6%) patients were diagnosed with OSA. The RVEF significantly decreased with the severity of OSA (none, mild, moderate-severe: 46.1 ± 8.2 vs 42.9 ± 7.5 vs 41.4 ± 7.4, P = .009). The apnea-hypopnea index (AHI) was significantly high in patients with RVEF<40% among the different OSA groups (mild, moderate:7.7 ± 2.4 vs 9.6 ± 2.9, P = .03; 24.4 ± 9.0 vs 36.3 ± 18.0, P = .01). In the multiple linear regression model, the right ventricular end-systolic volume (β = -0.28, P < .001), AHI (β = -0.09, P = .02), and oxygen desaturation index (β = -0.11, P = .04) were independently associated with a decrease in RVEF (adjusted R
conclusionIn patients with HOCM, the presence and severity of OSA is independently associated with a lower RVEF. In addition, compared with patients with RVEF>40%, those with RVEF<40% had more symptoms, including chest pain, chest distress, and NYHA class III or IV.
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