Evidence map›Paper›PMID 32936320›Full record

ReviewPflugers Archiv : European journal of physiology2021

Taste transduction and channel synapses in taste buds.

Akiyuki Taruno, Kengo Nomura, Tsukasa Kusakizako, Zhongming Ma, Osamu Nureki, J Kevin Foskett

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06093256 (Orthodontic Fixed Appliances' Impact on Taste Perception Among Orthodontic Patients), which is not on this map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06093256 unknown statusnot on this mapstarted 2023, after this paper: background citation

Orthodontic Fixed Appliances' Impact on Taste Perception Among Orthodontic Patients: A Prospective Cohort Study

TypeobservationalSponsorRiyadh Elm UniversityRan2023 to 2024Enrolled40ConditionsTaste Perception, Fixed Orthodontic AppliancesArmsFixed orthodontic appliances
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 133 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Dual functions of SNAP25 in mouse taste buds.The Journal of physiology · 2025
    Article
  10. The enigma of type III taste bud cells.The Journal of physiology · 2025
    Article
  11. Review
  12. Biological Actions of Bile Acids via Cell Surface Receptors.International journal of molecular sciences · 2025
    Review
  13. Article
  14. Article
  15. A deadly taste: linking bitter taste receptors and apoptosis.Apoptosis : an international journal on programmed cell death · 2025
    Review
  16. Article
  17. Review
  18. Intracellular cAMP signaling-induced CaPflugers Archiv : European journal of physiology · 2025
    Article
  19. Bitter taste receptors.Chemical senses · 2025
    Review
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Akiyuki TarunoDepartment of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. taruno@koto.kpu-m.ac.jp.ORCID 0000-0002-2342-0265
Kengo NomuraDepartment of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID 0000-0001-7182-4072
Tsukasa KusakizakoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-6186-6647
Zhongming MaDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6404-6214
Osamu NurekiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-1813-7008
J Kevin FoskettDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8854-0268
Kyoto Prefectural University of Medicine · JPThe University of Tokyo · JPUniversity of Pennsylvania · US

Funding

Molecular physiology of CALHM ion channelsR01DC018278 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN, MA, ZHONGMING · 2020 to 2024
$2.7M
Role of CALHM1 ion channel in taste transductionR01DC012538 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN, MA, ZHONGMING · 2013 to 2017
$1.7M
NIDCD NIH HHS R01 DC012538NIDCD NIH HHS R01 DC018278NIH HHS R01DC018278
6 · The paper itself

Abstract

The variety of taste sensations, including sweet, umami, bitter, sour, and salty, arises from diverse taste cells, each of which expresses specific taste sensor molecules and associated components for downstream signal transduction cascades. Recent years have witnessed major advances in our understanding of the molecular mechanisms underlying transduction of basic tastes in taste buds, including the identification of the bona fide sour sensor H

Indexed as

AnimalsHumansSynapsesSynaptic TransmissionTasteTaste BudsCALHMIon channelSensorySynapseTaste

Identifiers

PMID32936320
PMCPMC9386877
OpenAlexW3086077505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.