ArticleInvestigative ophthalmology & visual science2020
The Fovea in Retinopathy of Prematurity.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Effect of Prematurity on Foveal Development During Infancy: Increased Foveal Inner and Outer Retina Layer Thicknesses in Extremely Premature Infants.Investigative ophthalmology & visual science · 2026Observational
- Validating DevCheck: a semi-automated computer algorithm for measuring foveal immaturity in premature infants.Quantitative imaging in medicine and surgery · 2026Article
- Foveal Identification and Development in Prematurity-Implications on Zone Localization and Nutritional Supplementation.Investigative ophthalmology & visual science · 2025Observational
- Long-Term Ocular Outcomes of Prematurity: Morphological Alterations, Visual Aspects and Implications for Age-Related Ocular Diseases.Journal of clinical medicine · 2025Review
- The effect of retinopathy of prematurity on visual acuity, refraction, biometric values, retinal and choroidal thickness in school-aged children.BMC ophthalmology · 2025Article
- Delayed macular development in preterm infants with spontaneously regressed retinopathy of prematurity.BMC ophthalmology · 2025Observational
- The Surviving, Not Thriving, Photoreceptors in Patients withDiagnostics (Basel, Switzerland) · 2024Article
- Evolutionary and developmental specialization of foveal cell types in the marmoset.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Peak Cone Density Predicted from Outer Segment Length Measured on Optical Coherence Tomography.Current eye research · 2024Article
- The Development of Retinal Function and Refractive Error in Children With Retinopathy of Prematurity.Investigative ophthalmology & visual science · 2023Article
- Structural impact of arrested foveal development in children born extremely preterm without ROP at 6.5 years of age.Eye (London, England) · 2023Article
- Preterm infant retinal OCT markers of perinatal health and retinopathy of prematurity.Frontiers in pediatrics · 2023Review
- Most nonpathological eyes present a small area of hyperreflective Henle's fiber layer on pupil-centered optical coherence tomography.International ophthalmology · 2022Article
- Insights into the developing fovea revealed by imaging.Progress in retinal and eye research · 2022Review
- Foveal Curvature and Its Associations in UK Biobank Participants.Investigative ophthalmology & visual science · 2022Article
- Characterization of Foveal Development in Treatment-Naïve Extremely Preterm Infants.Translational vision science & technology · 2022Article
- Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology.PloS one · 2022Article
- Assessing Foveal Structure in Individuals withOphthalmology science · 2021Article
- Association of Birth Weight With Foveolar Thickness in Adulthood: Results From a Population-Based Study.Investigative ophthalmology & visual science · 2021Article
- Foveal Pit Morphology Characterization: A Quantitative Analysis of the Key Methodological Steps.Entropy (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Purpose: Because preterm birth and retinopathy of prematurity (ROP) are associated with poor visual acuity (VA) and altered foveal development, we evaluated relationships among the central retinal photoreceptors, postreceptor retinal neurons, overlying fovea, and VA in ROP. Methods: We obtained optical coherence tomograms (OCTs) in preterm born subjects with no history of ROP (none; n = 61), ROP that resolved spontaneously without treatment (mild; n = 51), and ROP that required treatment by laser ablation of the avascular peripheral retina (severe; n = 22), as well as in term born control subjects (term; n = 111). We obtained foveal shape descriptors, measured central retinal layer thicknesses, and demarcated the anatomic parafovea using automated routines. In subsets of these subjects, we obtained OCTs eccentrically through the pupil (n = 46) to reveal the fiber layer of Henle (FLH) and obtained adaptive optics scanning light ophthalmograms (AO-SLOs) of the parafoveal cones (n = 34) and measured their spacing and distribution. Results: Both VA and foveal depth decreased with increasing ROP severity (term, none, mild, severe). In severe subjects, foveae were broader than normal and the parafovea was significantly enlarged compared to every other group. The FLH was thinner than normal in mild (but not severe) subjects. VA was associated with foveal depth more than group. Density of parafoveal cones did not differ significantly among groups. Conclusions: Foveal structure is associated with loss of VA in ROP. The preserved FLH in severe (relative to mild) eyes suggests treatment may help cone axon development. The significantly larger parafovea and increased outer nuclear layer (ONL) thickness in ROP hint that some developmental process affecting the photoreceptors is not arrested in ROP but rather is supranormal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.