Evidence map›Paper›PMID 32936024›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

Alveolar CCN1 is associated with mechanical stretch and acute respiratory distress syndrome severity.

Eric D Morrell, Serge Grazioli, Chi Hung, Osamu Kajikawa, Susanna Kosamo, Renee D Stapleton, Sina A Gharib, Laura Amado-Rodríguez, Guillermo Albaiceta, Mark M Wurfel and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Molecular insights using spatial transcriptomics of the distal lung in congenital diaphragmatic hernia.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  8. Highway toFrontiers in pharmacology · 2022
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Eric D MorrellDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington.
Serge GrazioliDivision of Neonatal and Pediatric Intensive Care, Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland.
Chi HungDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington.
Osamu KajikawaDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington.
Susanna KosamoDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington.
Renee D StapletonDepartment of Medicine, University of Vermont, Burlington, Vermont.
Sina A GharibDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington.
Laura Amado-RodríguezCentro de Investigación Biomédica En Red-Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Guillermo AlbaicetaCentro de Investigación Biomédica En Red-Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Mark M WurfelDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington.
Gustavo Matute-BelloDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington.
University of Washington · USCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESUniversity Hospital of Geneva · CHUniversity of Vermont · USVA Puget Sound Health Care System · US

Funding

SCCOR in Translational Research in Acute Lung InjuryP50HL073996 · NHLBI · UNIVERSITY OF WASHINGTON · PI MARTIN, THOMAS R · 2003 to 2007
$15.7M
The Role of Alveolar Mononuclear Phagocytes in Acute Respiratory Distress SyndromeK23HL144916 · NHLBI · UNIVERSITY OF WASHINGTON · PI MORRELL, ERIC DOUGLAS · 2019 to 2023
$951k
Role of integrin alpha 8 in resolution of lung injury and repairK08HL127075 · NHLBI · UNIVERSITY OF WASHINGTON · PI HUNG, CHI F · 2015 to 2019
$778k
BLRD VA I01 BX002914NHLBI NIH HHS K08 HL127075NHLBI NIH HHS K23 HL144916NHLBI NIH HHS P50 HL073996NIH HHS K23 HL144916NIH HHS P50 HL073996Veterans Affairs Biomedical Laboratory Service I01BX002914
6 · The paper itself

Abstract

The cellular communication network factor 1 (CCN1) is a matricellular protein that can modulate multiple tissue responses, including inflammation and repair. We have previously shown that adenoviral overexpression of

Indexed as

Respiration, ArtificialAcute Lung InjuryAnimalsBronchoalveolar Lavage FluidCysteine-Rich Protein 61InflammationLungMiceRespiratory Distress SyndromeVentilator-Induced Lung InjuryCCN1 protein, mouseCysteine-Rich Protein 61acute lung injuryacute respiratory distress syndromeCCN1

Identifiers

PMID32936024
PMCPMC7789974
OpenAlexW3087297673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.