ArticleAmerican journal of physical anthropology2021
Leveraging genetic ancestry to study health disparities.
Article in American journal of physical anthropology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- Recommendations for the ethical and accurate use of population descriptors: a trainee-led survey of early-career researchers.bioRxiv : the preprint server for biology · 2026Article
- Platelet-Prostate cancer crosstalk driving disparities and therapeutic vulnerabilities.Discover oncology · 2026Review
- Ancestry-informative markers and variants of uncertain significance on hereditary cancer panels.Frontiers in oncology · 2026Article
- Placental biology links genetic, epigenetic, ancestral, and social determinants to maternal-fetal health inequities.Frontiers in reproductive health · 2026Review
- Unveiling Disparities: Analyzing Hispanic Inclusion in Liver Cancer Research Databases in the United States.Journal of racial and ethnic health disparities · 2025Article
- Associations of self-identified race and ethnicity and genetic ancestry with mortality among cancer survivors.Journal of the National Cancer Institute · 2025Article
- Ethnic diversity in precision medicine: a reality or an aspiration?Diabetologia · 2025Review
- Echoes of Inequity: A Critical Examination of the Past, Present, and Future of Cardiac Health Equity.Current cardiology reports · 2025Review
- Maternal obesity and ancestry distance in influencing birth outcomes.International journal of obesity (2005) · 2025Observational
- Genomic landscape of cancer in racially and ethnically diverse populations.Nature reviews. Genetics · 2025Review
- African Genetic Ancestry, Structural and Social Determinants of Health, and Mortality in Black Adults.JAMA network open · 2025Article
- Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations.Cancer discovery · 2025Article
- Article
- Revisiting HER2 in Prostate Cancer from an Inclusive Perspective: From Biomarkers to Omics.Cancers · 2024Review
- Aspiring toward equitable benefits from genomic advances to individuals of ancestrally diverse backgrounds.American journal of human genetics · 2024Review
- Racial Disparities in Pediatric Inflammatory Bowel Disease Care: Differences in Outcomes and Health Service Utilization Between Black and White Children.The Journal of pediatrics · 2023Article
- Guidelines for genetic ancestry inference created through roundtable discussions.HGG advances · 2023Article
- Evolutionary Genetics and Admixture in African Populations.Genome biology and evolution · 2023Review
- Brain morphological variability between whites and African Americans: the importance of racial identity in brain imaging research.Frontiers in integrative neuroscience · 2023Article
- Ancestry: How researchers use it and what they mean by it.Frontiers in genetics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Research to understand human genomic variation and its implications in health has great potential to contribute in the reduction of health disparities. Biological anthropology can play important roles in genomics and health disparities research using a biocultural approach. This paper argues that racial/ethnic categories should not be used as a surrogate for sociocultural factors or global genomic clusters in biomedical research or clinical settings, because of the high genetic heterogeneity that exists within traditional racial/ethnic groups. Genetic ancestry is used to show variation in ancestral genomic contributions to recently admixed populations in the United States, such as African Americans and Hispanic/Latino Americans. Genetic ancestry estimates are also used to examine the relationship between ancestry-related biological and sociocultural factors affecting health disparities. To localize areas of genomes that contribute to health disparities, admixture mapping and genome-wide association studies (GWAS) are often used. Recent GWAS have identified many genetic variants that are highly differentiated among human populations that are associated with disease risk. Some of these are population-specific variants. Many of these variants may impact disease risk and help explain a portion of the difference in disease burden among racial/ethnic groups. Genetic ancestry is also of particular interest in precision medicine and disparities in drug efficacy and outcomes. By using genetic ancestry, we can learn about potential biological differences that may contribute to the heterogeneity observed across self-reported racial groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.