ArticleSleep2021
Sleep deficits and cannabis use behaviors: an analysis of shared genetics using linkage disequilibrium score regression and polygenic risk prediction.
Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sleep quality of adult recreational cannabis users: a systematic review of literature.Trends in psychiatry and psychotherapy · 2025Pooled it
- Chronotype, Genetic Risk, Lifestyle, and Risk of Depression and Anxiety: A Prospective Cohort Study.MedComm · 2026Article
- Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence.Journal of adolescence · 2026Article
- Co-morbid cannabis use disorder and chronotype are associated with mood symptom onset in people with bipolar disorder.Journal of psychiatric research · 2024Article
- Sleep-Related Predictors of Risk for Alcohol Use and Related Problems in Adolescents and Young Adults.Alcohol research : current reviews · 2024Review
- A Review of the Effects of Adolescent Cannabis Use on Physical Health.The Psychiatric clinics of North America · 2023Review
- Chronotype and mental health: timing seems to matter, but how, why, and for whom?World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Development of morning-eveningness in adolescence: implications for brain development and psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- A Review of the Effects of Adolescent Cannabis Use on Physical Health.Child and adolescent psychiatric clinics of North America · 2023Review
- Daily-level associations between sleep duration and next-day alcohol and cannabis craving and use in young adults.Addictive behaviors · 2022Article
- Characterisation of the genetic relationship between the domains of sleep and circadian-related behaviours with substance use phenotypes.Addiction biology · 2022Article
- Self-reported sleep and circadian characteristics predict alcohol and cannabis use: A longitudinal analysis of the National Consortium on Alcohol and Neurodevelopment in Adolescence Study.Alcoholism, clinical and experimental research · 2022Article
- When Cannabis Use Goes Wrong: Mental Health Side Effects of Cannabis Use That Present to Emergency Services.Frontiers in psychiatry · 2021Review
- Mental Health, Substance Use, and Related Factors Associated with Recent Use of Cannabis for Sleep: A Co-Twin Control Study.Behavioral sleep medicineArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
STUDY
objectivesEstimate the genetic relationship of cannabis use with sleep deficits and an eveningness chronotype.
methodsWe used linkage disequilibrium score regression (LDSC) to analyze genetic correlations between sleep deficits and cannabis use behaviors. Secondly, we generated sleep deficit polygenic risk score (PRS) and estimated their ability to predict cannabis use behaviors using linear and logistic regression. Summary statistics came from existing genome-wide association studies of European ancestry that were focused on sleep duration, insomnia, chronotype, lifetime cannabis use, and cannabis use disorder (CUD). A target sample for PRS prediction consisted of high-risk participants and participants from twin/family community-based studies (European ancestry; n = 760, male = 64%; mean age = 26.78 years). Target data consisted of self-reported sleep (sleep duration, feeling tired, and taking naps) and cannabis use behaviors (lifetime ever use, number of lifetime uses, past 180-day use, age of first use, and lifetime CUD symptoms).
resultsSignificant genetic correlation between lifetime cannabis use and an eveningness chronotype (rG = 0.24, p < 0.001), as well as between CUD and both short sleep duration (<7 h; rG = 0.23, p = 0.017) and insomnia (rG = 0.20, p = 0.020). Insomnia PRS predicted earlier age of first cannabis use (OR = 0.92, p = 0.036) and increased lifetime CUD symptom count (OR = 1.09, p = 0.012).
conclusionCannabis use is genetically associated with both sleep deficits and an eveningness chronotype, suggesting that there are genes that predispose individuals to both cannabis use and sleep deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.