ArticleJournal of the American Chemical Society2020
Supramolecular Double Helices from Small C
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Supramolecular Polymer-Surfactant Co-Assemblies for Multivalent HSV-1 Inhibition.Angewandte Chemie (International ed. in English) · 2026Article
- Supramolecules for Pathogen Inhibition: From Polymers to Self-Assembled Nanosystems.Accounts of materials research · 2026Article
- Unlocking a Biological Interface of Chiral Supramolecular Helical Polymers.Journal of the American Chemical Society · 2025Article
- Article
- Amplification of Asymmetry via Structural Transitions in Supramolecular Polymer-Surfactant Coassemblies.Journal of the American Chemical Society · 2025Article
- Antibody-Recruiting Surfaces Using Adaptive Multicomponent Supramolecular Copolymers.Biomacromolecules · 2025Article
- Secondary nucleation guided noncovalent synthesis of dendritic homochiral superstructures via growth on and from surface.Nature communications · 2024Article
- Synthetic, multi-dynamic hydrogels by uniting stress-stiffening and supramolecular polymers.Science advances · 2024Article
- Bimolecular Sandwich Aggregates of Porphyrin Nanorings.Journal of the American Chemical Society · 2024Article
- Molecularly Engineered Supramolecular Thermoresponsive Hydrogels with Tunable Mechanical and Dynamic Properties.Biomacromolecules · 2024Article
- Visualizing the Heterogeneity in Homogeneous Supramolecular Polymers.Journal of the American Chemical Society · 2024Article
- Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel-Cell Interactions.Journal of the American Chemical Society · 2024Review
- Near-atomic-resolution structure of J-aggregated helical light-harvesting nanotubes.Nature chemistry · 2024Article
- Structural Elucidation of a Polypeptoid Chain in a Crystalline Lattice Reveals Key Morphology-Directing Role of the N-Terminus.ACS nano · 2023Article
- Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels.Chemical communications (Cambridge, England) · 2023Article
- Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell Cytotoxicity.ACS omega · 2022Article
- Supramolecular Stability of Benzene-1,3,5-tricarboxamide Supramolecular Polymers in Biological Media: Beyond the Stability-Responsiveness Trade-off.Journal of the American Chemical Society · 2022Article
- Structure and Dynamics of Supramolecular Polymers: Wait and See.ACS macro letters · 2022Article
- Choline-Functionalized Supramolecular Copolymers: Toward Antimicrobial Activity againstBiomacromolecules · 2021Article
- Introducing Hyaluronic Acid into Supramolecular Polymers and Hydrogels.Biomacromolecules · 2021Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Supramolecular fibers in water, micrometers long and several nanometers in width, are among the most studied nanostructures for biomedical applications. These supramolecular polymers are formed through a spontaneous self-assembly process of small amphiphilic molecules by specific secondary interactions. Although many compounds do not possess a stereocenter, recent studies suggest the (co)existence of helical structures, albeit in racemic form. Here, we disclose a series of supramolecular (co)polymers based on water-soluble benzene-1,3,5-tricarboxamides (BTAs) that form double helices, fibers that were long thought to be chains of single molecules stacked in one dimension (1D). Detailed cryogenic transmission electron microscopy (cryo-TEM) studies and subsequent three-dimensional-volume reconstructions unveiled helical repeats, ranging from 15 to 30 nm. Most remarkable, the pitch can be tuned through the composition of the copolymers, where two different monomers with the same core but different peripheries are mixed in various ratios. Like in lipid bilayers, the hydrophobic shielding in the aggregates of these disc-shaped molecules is proposed to be best obtained by dimer formation, promoting supramolecular double helices. It is anticipated that many of the supramolecular polymers in water will have a thermodynamic stable structure, such as a double helix, although small structural changes can yield single stacks as well. Hence, it is essential to perform detailed analyses prior to sketching a molecular picture of these 1D fibers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.