Evidence map›Paper›PMID 32935530›Full record

ArticleObesity (Silver Spring, Md.)2020

Human Milk Oligosaccharides and Hispanic Infant Weight Gain in the First 6 Months.

Paige K Berger, Jasmine F Plows, Roshonda B Jones, Tanya L Alderete, Chloe Yonemitsu, Ji Hoon Ryoo, Lars Bode, Michael I Goran

Open access · greenAbstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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  15. Biology of human milk oligosaccharides: From basic science to clinical evidence.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Paige K BergerDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
Jasmine F PlowsDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
Roshonda B JonesDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
Tanya L AldereteDepartment of Integrative Physiology, University of Colorado, Boulder, Boulder, Colorado, USA.
Chloe YonemitsuDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Ji Hoon RyooDepartment of Education, Yonsei University, Seoul, South Korea.
Lars BodeDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Michael I GoranDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-6897-6961
Children's Hospital of Los Angeles · USUniversity of California San Diego · USUniversity of Colorado Boulder · USYonsei University · KR

Funding

Impact of Sugars and Human Milk Oligosaccharides on Infant Microbiome and ObesityR01DK110793 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC, PETERSON, BRADLEY S · 2017 to 2024
$6.0M
Role of Human Milk Oligosaccharides on Brain Development in Preterm InfantsR00HD098288 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BERGER, PAIGE KIMBERLY · 2022 to 2024
$686k
Role of Human Milk Oligosaccharides on Infant Brain DevelopmentK99HD098288 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI BERGER, PAIGE KIMBERLY · 2020 to 2021
$180k
NICHD NIH HHS K99 HD098288NICHD NIH HHS R00 HD098288NIDDK NIH HHS R01 DK110793
6 · The paper itself

Abstract

objectiveThe aim of this study was to determine whether human milk oligosaccharides (HMOs) at 1 month predicted infant weight gain at 6 months and whether associations varied by HMO secretor status.

methodsParticipants were 157 Hispanic mother-infant pairs. Human milk samples were collected at 1 month. Nineteen individual HMOs were analyzed using high-performance liquid chromatography, and secretor status was determined by the presence of 2'-fucosyllactose or lacto-N-fucopentaose (LNFP) I. Infant weight was measured at 1 and 6 months. Path analysis was used to test effects of HMO composition on infant weight gain, adjusting for maternal age, prepregnancy BMI, and infant age, sex, and birth weight.

resultsIn the total sample, higher LNFPII predicted lower infant weight gain (g

conclusionsOur data suggest that higher LNFPII in human milk may decrease obesity risk across all infants, whereas higher lacto-N-neotetraose and disialyllacto-N-tetraose may increase obesity risk in infants of nonsecretors only.

Indexed as

AdultFemaleHispanic or LatinoHumansInfantInfant, NewbornMaleMilk, HumanOligosaccharidesTime FactorsWeight GainOligosaccharides

Identifiers

PMID32935530
PMCPMC7822565
OpenAlexW3044779538

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.