Evidence map›Paper›PMID 32935500›Full record

ArticleJournal of biomedical optics2020

Water wavenumber calibration for visible light optical coherence tomography.

Tingwei Zhang, Aaron M Kho, Vivek J Srinivasan

Abstract readLetter
In one paragraph

Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Frontiers in cellular neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tingwei ZhangUniversity of California Davis, Department of Biomedical Engineering, Davis, California, United States.
Aaron M KhoUniversity of California Davis, Department of Biomedical Engineering, Davis, California, United States.
Vivek J SrinivasanUniversity of California Davis, Department of Biomedical Engineering, Davis, California, United States.

Funding

True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence TomographyR01EY031469 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2020 to 2023
$2.3M
Human Brain Interferometers for Better Blood Flow MonitoringR01EB029747 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2020 to 2023
$2.2M
Imaging Neuronal and Capillary Dysfunction Deep in the Rodent Brain in vivo Using 1700 NM Optical Coherence Microscopy and Tracer-Based KineticsR01NS094681 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2015 to 2019
$1.6M
Development, Validation and Application of Metabolic Imaging in GlaucomaR01EY028287 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO, GOLDBERG, JEFFREY L · 2017 to 2019
$1.1M
NEI NIH HHS R01 EY028287NEI NIH HHS R01 EY031469NIBIB NIH HHS R01 EB029747NINDS NIH HHS R01 NS094681
6 · The paper itself

Abstract

significanceVisible light optical coherence tomography (OCT) is emerging for spectroscopic and ultrahigh resolution imaging, but challenges remain. Depth-dependent dispersion limits retinal image quality and current correction approaches are cumbersome. Inconsistent group refractive indices during image reconstruction also limit reproducibility.

aimTo introduce and evaluate water wavenumber calibration (WWC), which corrects depth-dependent dispersion and provides an accurate depth axis in water. APPROACH: Enabled by a visible light OCT spectrometer configuration with a 3- to 4-dB sensitivity roll-off over 1 mm in air across a 90-nm bandwidth, we determine the spectral phase of a 1-mm water cell, an affine function of water wavenumber. Via WWC, we reconstruct visible light OCT human retinal images with 1.3-μm depth resolution in water.

resultsImages clearly reveal Bruch's membrane, inner plexiform layer lamination, and a thin nerve fiber layer in the temporal parafovea. WWC halves the processing time, while achieving the same image definition as an assumption-free gold standard approach, suggesting that water wavenumber is a suitable proxy for tissue wavenumber. WWC also provides a depth axis in water without explicitly assuming a group refractive index.

conclusionsWWC is a simple method that helps to realize the full potential of visible light OCT.

Indexed as

Tomography, Optical CoherenceWaterCalibrationHumansLightReproducibility of ResultsWaterdispersion compensationoptical coherence tomographyretinal imagingwavenumber calibration

Identifiers

PMID32935500
PMCPMC7490762

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.