Evidence map›Paper›PMID 32935274›Full record

ArticleJournal of molecular neuroscience : MN2021

Evaluation of the Serum Dkk-1, Tenascin-C, Oxidative Stress Markers Levels and Wnt Signaling Pathway Genes Expression in Patients with Alzheimer's Disease.

Zahra Hasanzadeh, Alireza Nourazarian, Masoud Nikanfar, Delara Laghousi, Amir Mansour Vatankhah, Somayeh Sadrirad

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Serum Levels of Wnt/β-catenin Pathway Regulators Dkk-1, PORCN, Notum, and Tiki-1 in Children with Autism Spectrum Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Role of the Extracellular Matrix in Alzheimer's Disease.Frontiers in aging neuroscience · 2021
    Review
  7. WNT Signaling Is a Key Player in Alzheimer's Disease.Handbook of experimental pharmacology · 2021
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zahra HasanzadehDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Alireza NourazarianDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Nourazariana@tbzmed.ac.ir.ORCID http://orcid.org/0000-0003-2082-1335
Masoud NikanfarDepartment of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Delara LaghousiSocial Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Amir Mansour VatankhahDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Somayeh SadriradDepartment of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Tabriz University of Medical Sciences · IR

Funding

Drug Applied Research Center, Tabriz University of Medical Sciences IR.TBZMED.REC.1397.333
6 · The paper itself

Abstract

Early diagnosis of Alzheimer's disease (AD) using potential biomarkers may help with implementing early therapeutic interventions, monitoring, and ultimately disease treatment. The current study aimed to evaluate serum levels of DKK-1, TNC, and oxidative stress markers, as well as analyzing the expression of LRP6, GSK3A, and GSK3B genes in patients with AD. Serum levels of DKK-1, TNC, TOS, TAC, and MDA were measured in 40 AD patients and 40 healthy individuals. Additionally, the relative expressions of LRP6, GSK3A, and GSK3B genes in whole blood were evaluated. Receiver operating characteristic (ROC) analysis was used to investigate the incremental diagnostic value of each factor in the study groups. Mean serum levels of DKK-1, TNC, TOS, TAC, and MDA were significantly higher in the AD group compared to the healthy group (p < 0.001). Moreover, a significant difference was observed in the expression of LRP6 and GSK3A genes (p < 0.001) between patients and healthy groups. However, the expression of GSK3B did not significantly differ between the two groups (p > 0.05). With considerable sensitivity and specificity, ROC analysis demonstrated the diagnostic efficacy of DKK-1 and TNC serum levels in AD within an area under the ROC curve of ≥ 0.98 (p ˂ 0.001). The results showed that evaluating serum levels of DKK-1 and TNC, as well as assessing the expression of LRP6, could be utilized for diagnosis and monitoring of AD patients.

Indexed as

Oxidative StressWnt Signaling PathwayAgedAged, 80 and overAlzheimer DiseaseBiomarkersFemaleGlycogen Synthase Kinase 3HumansIntercellular Signaling Peptides and ProteinsLow Density Lipoprotein Receptor-Related Protein-6MaleMalondialdehydeMiddle AgedTenascinBiomarkersDKK1 protein, humanGlycogen Synthase Kinase 3Intercellular Signaling Peptides and ProteinsLow Density Lipoprotein Receptor-Related Protein-6LRP6 protein, humanMalondialdehydeTenascinTNC protein, humanAlzheimer's diseaseDKK-1Oxidative stressTNCWnt signaling

Identifiers

PMID32935274
OpenAlexW3086029347

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.