Evidence map›Paper›PMID 32935187›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

(+)-[

Solveig Tiepolt, Georg-Alexander Becker, Stephan Wilke, Diego Cecchin, Michael Rullmann, Philipp M Meyer, Henryk Barthel, Swen Hesse, Marianne Patt, Julia Luthardt and 11 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. The cholinergic basal forebrain and its role in neurodegeneration.Journal of neuropathology and experimental neurology · 2025
    Review
  3. Reduction in [Brain research · 2025
    Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 2 countries.

Solveig Tiepolt *Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany. Solveig.tiepolt@medizin.uni-leipzig.de.ORCID http://orcid.org/0000-0003-0378-8334
Georg-Alexander Becker *Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Stephan WilkeDepartment of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Diego CecchinDepartment of Medicine, University-Hospital of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Michael RullmannDepartment of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Philipp M MeyerDepartment of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Henryk BarthelDepartment of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Swen HesseDepartment of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Marianne PattDepartment of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Julia LuthardtDepartment of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Gudrun WagenknechtElectronic Systems (ZEA-2), Central Institute for Engineering, Electronics and Analytics, Research Centre Juelich, Wilhelm-Johnen-Straße, 52428, Juelich, Germany.
Bernhard SattlerDepartment of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Winnie Deuther-ConradHelmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Permoserstraße 15, 04318, Leipzig, Germany.
Friedrich-Alexander LudwigHelmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Permoserstraße 15, 04318, Leipzig, Germany.
Steffen FischerHelmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Permoserstraße 15, 04318, Leipzig, Germany.
Hermann-Josef GertzDepartment of Psychiatry, University of Leipzig, Semmelweisstraße 10, 04103, Leipzig, Germany.
René SmitsABX advanced biochemical compounds GmbH, Heinrich-Gläser-Straße 10, 01454, Radeberg, Germany.
Alexander HoeppingABX advanced biochemical compounds GmbH, Heinrich-Gläser-Straße 10, 01454, Radeberg, Germany.
Jörg SteinbachHelmholtz-Zentrum Dresden-Rossendorf, Bautzener Landstr. 400, 01328, Dresden, Germany.
Peter Brust *Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Permoserstraße 15, 04318, Leipzig, Germany.
Osama Sabri *Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Leipzig University · DEHelmholtz-Zentrum Dresden-Rossendorf · DEABX-CRO Advanced Pharmaceutical Services (Germany) · DEUniversity Hospital Leipzig · DEUniversity of Padua · IT

Funding

Helmholtz validation fond HVF-0012 "NikotinPET"
6 · The paper itself

Abstract

purposesWe present the first in-human brain PET imaging data of the new α4β2 nicotinic acetylcholine receptor (nAChR)-targeting radioligand (+)-[

methodsWe examined 11 HCs and 9 mild AD patients. All subjects underwent neuropsychological testing and [

resultsWith 270-min p.i., the unchanged parent compound amounted to 97 ± 2%. Adequate fits of the time-activity curves were obtained with the 1 tissue compartment model (1TCM). (+)-[

conclusion(+)-[

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAniline CompoundsBenzamidesBrainBridged Bicyclo Compounds, HeterocyclicHumansLigandsNeuroimagingPositron-Emission TomographyReceptors, NicotinicAmyloid beta-PeptidesAniline CompoundsBenzamidesBridged Bicyclo Compounds, HeterocyclicfluoronorchloroepibatidineLigandsnicotinic receptor alpha4beta2Receptors, Nicotinic(+)-[18F]Flubatine [(+)-[18F]NCFHEB]Human brainKinetic modelingPETα4β2 nicotinic acetylcholine receptors

Identifiers

PMID32935187
PMCPMC8036219
OpenAlexW3085744412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.