ArticleJournal of neurology2021
Assessment of Wearing Off in Parkinson's disease using objective measurement.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- High-dose versus low-dose inhaled levodopa (CVT-301) in patients with Parkinson disease for the treatment of OFF episodes: a meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Levodopa-induced alterations in vertical center of mass and muscle synergy structure during Parkinsonian gait.Experimental brain research · 2026Article
- A framework of digital biomarkers for neurodegenerative diseases.Nature reviews bioengineering · 2026Article
- Comparing Parkinson's Disease Medications Categorised by Location in New South Wales, Australia: Linking the 45 and Up Study and the Pharmaceutical Benefits Scheme (PBS) Data.The Australian journal of rural health · 2025Article
- Consensus on the clinical utility of digital mobility outcomes for personalized clinical decision support in parkinson's disease.Neurological research and practice · 2025Article
- The Development of a Quantitative Disability Assessment Tool in Patients with Idiopathic Parkinson's Disease.Diagnostics (Basel, Switzerland) · 2024Article
- Assessing the clinical utility of inertial sensors for home monitoring in Parkinson's disease: a comprehensive review.NPJ Parkinson's disease · 2024Article
- [Inhaled levodopa: from evidence to experience].Revista de neurologia · 2024Review
- Levodopa use in Australia: an analysis of Pharmaceutical Benefits Scheme 10% data.BMJ neurology open · 2024Article
- An Individualized Multi-Modal Approach for Detection of Medication "Off" Episodes in Parkinson's Disease via Wearable Sensors.Journal of personalized medicine · 2023Article
- A Digital Architecture for the Real-Time Tracking of Wearing off Phenomenon in Parkinson's Disease.Sensors (Basel, Switzerland) · 2022Article
- A quantitative systems pharmacology model for simulating OFF-Time in augmentation trials for Parkinson's disease: application to preladenant.Journal of pharmacokinetics and pharmacodynamics · 2022Article
- Sensor Measurements Can Characterize Fluctuations and Wearing Off in Parkinson's Disease and Guide Therapy to Improve Motor, Non-motor and Quality of Life Scores.Frontiers in aging neuroscience · 2022Article
- Rapid Dynamic Naturalistic Monitoring of Bradykinesia in Parkinson's Disease Using a Wrist-Worn Accelerometer.Sensors (Basel, Switzerland) · 2021Article
- A method for measuring time spent in bradykinesia and dyskinesia in people with Parkinson's disease using an ambulatory monitor.Journal of neuroengineering and rehabilitation · 2021Article
- The Experience of OFF Periods in Parkinson's Disease: Descriptions, Triggers, and Alleviating Factors.Journal of patient-centered research and reviews · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDevelopment of "Wearing Off" (WO) of motor and non-motor function in Parkinson's disease (PD) adversely affects quality of life. This suggest that identifying and treating WO is important. However, identification of WO depends on people with PD (PwP) recognising and reporting WO and there is a perception that WO may be significantly underestimated.
objectiveWe investigate the feasibility of identifying "Wearing Off" using objective measurement and assess the clinical benefit in rectifying it.
methodIn this study, 200 PwP were studied for evidence of WO using a continuously worn wearable system. Eighty-five patients (43%) were found to have WO and treatment was changed to mitigate the effects of WO.
resultsFactors, such as duration of disease, high baseline MDS-UPDRS (motor component), high Percent Time in Bradykinesia (PTB), high Levodopa Equivalent Daily Dose (LEDD), frequent Levodopa doses and younger age of onset, are associated with severity of motor complications. Patients with more severe WO experienced worse motor and non-motor symptoms and lower quality of life. Quality of life significantly improved in PwP when WO was treated.
conclusionThe findings reported in this study provide evidence that identifying and treating WO improves outcomes of PwP and that objective measurements may help clinicians to identify and treat WO.
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Registered trials
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