ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020
Neurological reasons for consultation and hospitalization during the COVID-19 pandemic.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
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15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Imaging Markers of Neurologic Damage in COVID-19: A Systematic Review.Current medicinal chemistry · 2023Pooled it
- Syncope and COVID-19 disease - A systematic review.Autonomic neuroscience : basic & clinical · 2021Pooled it
- What can the neurological manifestations of COVID-19 tell us: a meta-analysis.Journal of translational medicine · 2021Pooled it
- Neurological manifestations of patients infected with the SARS-CoV-2: a systematic review of the literature.Journal of neurology · 2021Pooled it
- Hemorrhagic and ischemic stroke in patients with coronavirus disease 2019: incidence, risk factors, and pathogenesis - a systematic review and meta-analysis.F1000Research · 2021Pooled it
- Long COVID-19 Pathophysiology: What Do We Know So Far?Microorganisms · 2023Review
- A 3R-Tau-mediated mechanism in oligodendrocytes: could it be the key for neuroprotection after stroke?Neural regeneration research · 2021Review
- Epidemiology, pathophysiology, and classification of the neurological symptoms of post-COVID-19 syndrome.Neurology perspectives · 2021Review
- COVID-19 outcomes of 10,881 patients: retrospective study of neurological symptoms and associated manifestations (Philippine CORONA Study).Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Cognitive impairment in a patient with COVID-19 on hemodialysis: Too dangerous to neglect!Hemodialysis international. International Symposium on Home Hemodialysis · 2021Article
- Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization.Nature communications · 2021Article
- Review
- Letter to the Editor Regarding: "COVID-19 and Neurosurgery Consultation Call Volume at a Single Large Tertiary Center with a Propensity-Adjusted Analysis".World neurosurgery · 2021Article
- In Reply to the Letter to the Editor Regarding "COVID-19 and Neurosurgery Consultation Call Volume at a Single Large Tertiary Center with a Propensity-Adjusted Analysis".World neurosurgery · 2021Article
- Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization.medRxiv : the preprint server for health sciences · 2020Article
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11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCOVID-19 disease affects the nervous system and led to an increase in neurological consults for patients at admission and through the period of hospitalization during the peak of the pandemic.
methodsPatients with clinical and laboratory diagnosis of COVID-19 that required a neurologic consultation or those who presented with neurological problems on admission that led to a diagnosis of SARS-CoV-2 infection during a 2-month period at the peak of the pandemic were included in this study. Demographic and clinical variables were analyzed.
resultsThirty-five patients were included. The presenting neurologic manifestations on admission led to the diagnosis of COVID-19 in 14 patients (40%). The most common reasons for consultation during the hospitalization period were stroke (11), encephalopathy (7), seizures (6), and neuropathies (5) followed by a miscellaneous of syncope (2), migraine (1), anosmia (1), critical illness myopathy (1), and exacerbation of residual dysarthria (1). The most common neurological disturbances were associated with severe disease except for neuropathies. Patients with encephalopathies and seizures had markedly increased D-dimer and ferritin values, even higher than stroke patients. RT-PCR was performed in 8 CSF samples and was negative in all of them.
conclusionNeurological disturbances represent a significant and severe burden in COVID-19 patients, and they can be the presenting condition that leads to the diagnosis of the viral infection in a high percentage of patients. Evidence of direct viral mechanisms was scarce, but the pathogenesis of the diverse manifestations remains enigmatic.
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