ArticleInternational journal of population data science2020
The Secure Anonymised Information Linkage databank Dementia e-cohort (SAIL-DeC).
Article in International journal of population data science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
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Who cites it
20 citing papers in PubMed.
- Risk of dementia after bloodstream infection-a nationwide propensity score matched cohort study.Age and ageing · 2026Article
- Identifying subjects at risk of liver cirrhosis via a range of thresholds for common fibrosis markers: A Welsh general population-based cohort study.Journal of internal medicine · 2026Article
- Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale.Science advances · 2025Article
- Observational
- Severe psychiatric disorders are associated with increased risk of dementia.BMJ mental health · 2024Article
- Health service use of infants involved in family justice care and supervision proceedings in Wales: a data linkage study.International journal of population data science · 2024Article
- Artificial intelligence for dementia-Applied models and digital health.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- Article
- Risk Factors Associated With Primary Care-Reported Domestic Violence for Women Involved in Family Law Care Proceedings: Data Linkage Observational Study.Journal of medical Internet research · 2023Observational
- The impact of dementia, frailty and care home characteristics on SARS-CoV-2 incidence in a national cohort of Welsh care home residents during a period of high community prevalence.Age and ageing · 2022Article
- Observational
- Trends in indirect liver function marker testing in Wales from 2000 to 2017 and their association with age and sex: an observational study.BMJ open gastroenterology · 2022Observational
- Associations between multimorbidity and adverse health outcomes in UK Biobank and the SAIL Databank: A comparison of longitudinal cohort studies.PLoS medicine · 2022Article
- Drug prescriptions and dementia incidence: a medication-wide association study of 17000 dementia cases among half a million participants.Journal of epidemiology and community health · 2022Article
- A methodology to facilitate critical care research using multiple linked electronic, clinical and administrative health records at population scale.International journal of population data science · 2022Article
- What gets recorded, counts: dementia recording in primary care compared with a specialist database.Age and ageing · 2021Article
- Using routinely recorded data in a UK RCT: a comparison to standard prospective data collection methods.Trials · 2021Article
- Article
- Article
- A Profile of the SAIL Databank on the UK Secure Research Platform.International journal of population data science · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
introductionThe rising burden of dementia is a global concern, and there is a need to study its causes, natural history and outcomes. The Secure Anonymised Information Linkage (SAIL) Databank contains anonymised, routinely-collected healthcare data for the population of Wales, UK. It has potential to be a valuable resource for dementia research owing to its size, long follow-up time and prospective collection of data during clinical care.
objectivesWe aimed to apply reproducible methods to create the SAIL dementia e-cohort (SAIL-DeC). We created SAIL-DeC with a view to maximising its utility for a broad range of research questions whilst minimising duplication of effort for researchers.
methodsSAIL contains individual-level, linked primary care, hospital admission, mortality and demographic data. Data are currently available until 2018 and future updates will extend participant follow-up time. We included participants who were born between 1st January 1900 and 1st January 1958 and for whom primary care data were available. We applied algorithms consisting of International Classification of Diseases (versions 9 and 10) and Read (version 2) codes to identify participants with and without all-cause dementia and dementia subtypes. We also created derived variables for comorbidities and risk factors.
resultsFrom 4.4 million unique participants in SAIL, 1.2 million met the cohort inclusion criteria, resulting in 18.8 million person-years of follow-up. Of these, 129,650 (10%) developed all-cause dementia, with 77,978 (60%) having dementia subtype codes. Alzheimer's disease was the most common subtype diagnosis (62%). Among the dementia cases, the median duration of observation time was 14 years.
conclusionWe have created a generalisable, national dementia e-cohort, aimed at facilitating epidemiological dementia research.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.