Evidence map›Paper›PMID 32934886›Full record

ReviewOncoimmunology2020

IL15 synergizes with radiotherapy to reprogram the tumor immune contexture through a dendritic cell connection.

Karsten A Pilones, Maud Charpentier, Elena Garcia-Martinez, Sandra Demaria

Abstract readReview
In one paragraph

Review in Oncoimmunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karsten A PilonesDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-0982-3260
Maud CharpentierDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-7343-4163
Elena Garcia-MartinezHematology and Oncology Department, Hospital Universitario Morales Meseguer, Murcia, Spain.
Sandra DemariaDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-4426-0499

Funding

Cancer Cell Intrinsic Interferon-I pathway Activation by Fractionated RadiationR01CA201246 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEMARIA, SANDRA · 2016 to 2025
$3.9M
Individualized in situ vaccination by radiation and immunotherapyR01CA198533 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEMARIA, SANDRA · 2016 to 2020
$1.9M
NCI NIH HHS R01 CA198533NCI NIH HHS R01 CA201246
6 · The paper itself

Abstract

IL15 is a key cytokine for the activation and survival of anti-tumor effectors CD8

Indexed as

Interleukin-15NeoplasmsCD8-Positive T-LymphocytesDendritic CellsHumansKiller Cells, NaturalIL15 protein, humanInterleukin-15CD8 T-cellsdendritic cellsIL-15interferon type 1radiotherapy

Identifiers

PMID32934886
PMCPMC7466855

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.