ArticleSouthern African journal of HIV medicine2020
Future approaches to clearing the latent human immunodeficiency virus reservoir: Beyond latency reversal.
Article in Southern African journal of HIV medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWhile combined antiretroviral therapy (cART) allows near-normal life expectancy for people living with human immunodeficiency virus (HIV), it is unable to cure the infection and so life long treatment is required.
objectivesThe main barrier to curing HIV is the latent reservoir of cells, which is stable and resistant to cART.
methodCurrent approaches under investigation for clearing this reservoir propose a 'Shock and Kill' mechanism, in which active replication is induced in latent cells by latency reversal agents, theoretically allowing killing of the newly active cells.
resultsHowever, previous studies have failed to achieve depletion of the
conclusionFuture approaches to clearing the latent reservoir may bypass latency reversal through the use of drugs that selectively induce apoptosis in infected cells. Several classes of these pro-apoptotic drugs have shown promise in
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