Evidence map›Paper›PMID 32934830›Full record

ArticleSouthern African journal of HIV medicine2020

Feasibility of implementing same-day antiretroviral therapy initiation during routine care in Ekurhuleni District, South Africa: Retention and viral load suppression.

Nolundi Mshweshwe-Pakela, Bhakti Hansoti, Tonderai Mabuto, Deanna Kerrigan, Griffiths Kubeka, Elizabeth Hahn, Salome Charalambous, Christopher J Hoffmann

Abstract read
In one paragraph

Article in Southern African journal of HIV medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Article
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  10. Treatment Outcomes After Offering Same-Day Initiation of Human Immunodeficiency Virus Treatment-How to Interpret Discrepancies Between Different Studies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
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  13. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nolundi Mshweshwe-PakelaImplementation Research Division, The Aurum Institute, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-3123-5852
Bhakti HansotiDepartment of Emergency Medicine, Johns Hopkins School of Medicine, Baltimore, United States of America.ORCID https://orcid.org/0000-0003-0188-9764
Tonderai MabutoImplementation Research Division, The Aurum Institute, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-5784-746X
Deanna KerriganDepartment of Sociology, American University, Washington, United States of America.ORCID https://orcid.org/0000-0001-7401-9159
Griffiths KubekaImplementation Research Division, The Aurum Institute, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-0135-3241
Elizabeth HahnDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.ORCID https://orcid.org/0000-0003-2929-5335
Salome CharalambousImplementation Research Division, The Aurum Institute, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-7143-1009
Christopher J HoffmannImplementation Research Division, The Aurum Institute, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-9422-0519

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSame-day initiation (SDI) of antiretroviral therapy (ART) has been advocated as an approach to increase linkage to care and overall ART initiation. Clinical trials have demonstrated impressive benefits. However, questions regarding patient preparedness and retention in care remain for routine implementation of this approach.

objectivesIn this study, we sought to describe SDI of ART during routine care delivery and compare time to ART initiation on longitudinal care outcomes.

methodWe performed a retrospective chart review of 100 consecutive individuals, newly diagnosed with HIV, from 10 health facilities across Ekurhuleni, from January to July 2017. Records were reviewed for a period of 1 year post-diagnosis. Abstracted data included demographics, time to ART initiation, clinic visits and laboratory test results (including viral load testing).

resultsA total of 993 patient records were reviewed, of which 826 were included in the analysis. The majority of patients (752, 91%) had ART initiation recorded, of which 654 (79%) had ART initiated within 30 days, and 224 (27%) had SDI. Uptake of SDI of ART was higher among women (36% vs. 10.4%;

conclusionSame-day initiation of ART was successfully delivered with similar retention and viral load outcomes as subsequent initiation, providing re-assurance for scale-up of this strategy in routine care.

Indexed as

ARV initiationHIV testingimplementationprimary careSDI

Identifiers

PMID32934830
PMCPMC7479383

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.