Evidence map›Paper›PMID 32934814›Full record

ArticleBiomedical reports2020

Downregulated expression of microRNAs associated with cardiac hypertrophy and fibrosis in physiological pregnancy and the association with echocardiographically-evaluated myocardial function.

Ewa Szczerba, Agnieszka Zajkowska, Anna Bochowicz, Katarzyna Pankiewicz, Grzegorz Szewczyk, Grzegorz Opolski, Tomasz Maciejewski, Maciej Małecki, Anna Fijałkowska

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In one paragraph

Article in Biomedical reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ewa SzczerbaDepartment of Cardiology, Institute of Mother and Child, 01-211 Warsaw, Poland.
Agnieszka ZajkowskaDepartment of Applied Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland.
Anna BochowiczDepartment of Cardiology, Institute of Mother and Child, 01-211 Warsaw, Poland.
Katarzyna PankiewiczDepartment of Gynecology and Obstetrics, Institute of Mother and Child, 01-211 Warsaw, Poland.
Grzegorz SzewczykDepartment of Gynecology and Obstetrics, Institute of Mother and Child, 01-211 Warsaw, Poland.
Grzegorz OpolskiFirst Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland.
Tomasz MaciejewskiDepartment of Gynecology and Obstetrics, Institute of Mother and Child, 01-211 Warsaw, Poland.
Maciej MałeckiDepartment of Applied Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland.
Anna FijałkowskaDepartment of Cardiology, Institute of Mother and Child, 01-211 Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to analyze the profiles of cardiac microRNAs (miRNAs/miRs) in healthy pregnant women and non-pregnant controls. A total of 61 healthy women >18 years of age with singleton pregnancies in the third trimester were compared with 19 non-pregnant controls. Specifically, expression of miRNAs associated with cardiac hypertrophy (miR-1, miR-17-5, miR-22, miR-34a, miR-124, miR-133a, miR-195, miR-199a-3p, miR-199b, miR-210, miR-222 and miR-1249) and miRNAs associated with cardiac hypertrophy and fibrosis (miR-15b, miR-21, miR-26a, miR-29-a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. Both groups had similar cardiac miRNA expression profiles, but differed in quantitative evaluation. Women in the third trimester of physiological pregnancy exhibited downregulation of certain profibrotic miRNAs (miR-21, miR-30c and miR-328), decreased expression of a hypertrophic and antimetabolic miRNAs (miR-146a), downregulation of an antifibrotic miRNA (miR-222), and downregulation of a hypertrophic miRNA (miR-195). In pregnant women, the indices of systolic function were associated with miR-195 expression, and an interplay between miR-17-5p and diastolic function was observed. While the profiles of cardiac miRNAs expressed in healthy pregnant women and healthy non-pregnant controls were similar, these two groups differed in terms of expression of specific miRNAs. In the third trimester of physiological pregnancy, a downregulation of miR-17-5p, miR-21, miR-30c, miR-146a, miR-195, miR-222 and miR-328 was observed. The differences in the association between echocardiographic indices with miRNAs in pregnant and non-pregnant women suggest that miRNAs regulate both the structure and function of the pregnant heart, influencing cardiac muscle thickness as well as systolic and diastolic function.

Indexed as

cardiac adaptationhypertrophymicroRNApregnancyremodelingvolume overload

Identifiers

PMID32934814
PMCPMC7469559

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.