Evidence map›Paper›PMID 32934355›Full record

ArticleLeukemia2021

Prognostic value of high-sensitivity measurable residual disease assessment after front-line chemoimmunotherapy in chronic lymphocytic leukemia.

Rémi Letestu, Abdelmalek Dahmani, Marouane Boubaya, Lucile Baseggio, Lydia Campos, Bernard Chatelain, Agathe Debliquis, Bernard Drénou, Marie-Christine Jacob, Eric Legac and 20 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Flow Cytometric MRD Detection in Selected Mature B-Cell Malignancies.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Challenging the Value of Minimal Residual Disease in Predicting Outcome of Patients With Chronic Lymphocytic Leukemia.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Frontline treatment in CLL: the case for time-limited treatment.Hematology. American Society of Hematology. Education Program · 2021
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 3 countries.

Rémi LetestuLaboratoire d'Hématologie, APHP CHU Avicenne, Bobigny, France. remi.letestu@aphp.fr.ORCID http://orcid.org/0000-0002-2437-2656
Abdelmalek DahmaniLaboratoire d'Hématologie, APHP CHU Avicenne, Bobigny, France.
Marouane BoubayaURC, APHP CHU Avicenne, Bobigny, France.
Lucile BaseggioLaboratoire d'Hématologie, Hospices Civils de Lyon/Groupement Hospitalier Sud, Lyon, France.
Lydia CamposLaboratoire d'Hématologie, CHU Saint Etienne, Saint Etienne, France.
Bernard ChatelainLaboratoire d'Hématologie, CHU UCL Namur, Yvoir, Belgium.
Agathe DebliquisLaboratoire d'Hématologie, GHRMSA, Mulhouse, France.
Bernard DrénouLaboratoire d'Hématologie, GHRMSA, Mulhouse, France.ORCID http://orcid.org/0000-0002-2175-6785
Marie-Christine JacobLaboratoire d'Immunologie, CHU Grenoble-Alpes, Grenoble-Alpes, France.
Eric LegacLaboratoire d'Hématologie, CHR Orléans, Orléans, France.ORCID http://orcid.org/0000-0002-9205-0624
Magali Le Garff-TavernierLaboratoire d'Hématologie, APHP CHU Pitié-Salpêtrière, Paris, France.
Anne-Catherine LhoumeauLaboratoire d'Hématologie, IPC, Marseille, France.
Claire QuineyLaboratoire d'Hématologie, APHP CHU Pitié-Salpêtrière, Paris, France.
Nelly RobillardLaboratoire d'Hématologie, CHU Nantes, Nantes, France.
Michel TicchioniLaboratoire d'Immunologie, CHU L'Archet, Nice, France.
Carmen AaneiLaboratoire d'Hématologie, CHU Saint Etienne, Saint Etienne, France.
Sandrine KatsahianURC, CHU Saint-Louis, Paris, France.
Roselyne DelepineCHU Tours, Tours, France.
Sandrine VaudauxCLCC, Rouen, France.
Valérie RouilléCHU Montpellier, Montpellier, France.
Marie-Christine BénéLaboratoire d'Hématologie, CHU Nantes, Nantes, France.
Caroline DartigeasHématologie Clinique, CHU Tours, Tours, France.
Eric Van Den NesteHématologie Clinique, UCLouvain, Louvain, Belgium.
Stéphane LeprêtreHématologie Clinique, CLCC, Rouen, France.
Pierre FeugierHématologie Clinique, CHU Nancy, Nancy, France.
Guillaume CartronHématologie Clinique, CHU Montpellier, Montpellier, France.
Véronique LeblondHématologie clinique, APHP CHU Pitié-Salpêtrière, Sorbonne Université Paris, Paris, France.
Vincent LévyURC/CRC, APHP CHU Avicenne, Bobigny, France.
Florence CymbalistaLaboratoire d'Hématologie, APHP CHU Avicenne, Bobigny, France. florence.cymbalista@aphp.fr.
French Innovative Leukemia Organization (FILO)
Sorbonne Université · FRCentre Hospitalier Universitaire de Clermont-Ferrand · FRCentre Hospitalier Universitaire d'Angers · FRHôpital Avicenne · FRHôpital d'Hautepierre · FRAssistance Publique – Hôpitaux de Paris · FRCentre Hospitalier Annecy Genevois · FRCentre Hospitalier de la Côte Basque · FRCentre Hospitalier Sud Francilien · FRCentre Hospitalier Universitaire de Besançon · FRCentre Hospitalier Universitaire de Tours · FRCentre hospitalier universitaire d'Orléans · FRCentre Hospitalier Universitaire Henri-Mondor · FRHôpital Cardiologique du Haut-Lévêque · FRHôpital d'Enfants · FRHôpital Dupuytren · FRHôpital Nord · FRHôpital Saint Eloi · FRInstitute Cancer De La Loire Lucien Neuwirth · FRMercy Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Measurable residual disease (MRD) status is widely adopted in clinical trials in patients with chronic lymphocytic leukemia (CLL). Findings from FILO group trials (CLL2007FMP, CLL2007SA, CLL2010FMP) enabled investigation of the prognostic value of high-sensitivity (0.7 × 10

Indexed as

AgedAntineoplastic Combined Chemotherapy ProtocolsBone MarrowClinical Trials, Phase II as TopicClinical Trials, Phase III as TopicCyclophosphamideFemaleFollow-Up StudiesHumansImmunotherapyLeukemia, Lymphocytic, Chronic, B-CellMaleNeoplasm, ResidualPrognosisRetrospective StudiesRituximabCyclophosphamidefludarabineRituximabVidarabine

Identifiers

PMID32934355
OpenAlexW3087507522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.