Evidence map›Paper›PMID 32934336›Full record

ArticleScientific reports2020

Elevated IL-6R on CD4

Chaman Saini, Rupesh K Srivastava, Mohd Tarique, Santosh Kurra, Neena Khanna, V Ramesh, Alpana Sharma

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. CD4European journal of immunology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization.Revista da Sociedade Brasileira de Medicina Tropical · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Chaman SainiDepartment of Biotechnology, All India Institute of Medical Sciences, New Delhi, India. chamansaini82@gmail.com.
Rupesh K SrivastavaDepartment of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.
Mohd TariqueDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Santosh KurraDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Neena KhannaDepartment of Dermatology, All India Institute of Medical Sciences, New Delhi, India.
V RameshDepartment of Dermatology, Safdarjung Hospital, New Delhi, India.
Alpana SharmaDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India. dralpanasharma@gmail.com.
All India Institute of Medical Sciences · INDepartment of Biotechnology · INSafdarjang Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Th17 cells play vital role during pathogenesis of leprosy reactions. Previously, we have reported that IL-23 is involved in Th17 cells differentiation. Subsequently, our group also showed that IL-6 induces Th17 cell differentiation along with TGF-β in leprosy reactions. Here, we next asked the question that whether IL-6 or IL-23 induced Th17 cells are different in nature? In this study, Type 1 Reactions (T1R) showed significantly (p < 0.001) higher percentage of IL-17A producing CD4

Indexed as

AdolescentAdultCD4-Positive T-LymphocytesFemaleHumansInterleukin-17Interleukin-6LeprosyMaleMycobacterium lepraeReceptors, Interleukin-6Signal TransductionTh17 CellsT-Lymphocytes, RegulatoryTransforming Growth Factor betaYoung AdultIL17A protein, humanIL6 protein, humanIL6R protein, humanInterleukin-17Interleukin-6Receptors, Interleukin-6Transforming Growth Factor beta

Identifiers

PMID32934336
PMCPMC7493991
OpenAlexW3087441772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.