ArticleCommunications biology2020
The reliability and heritability of cortical folds and their genetic correlations across hemispheres.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Associations Between Teenage Motherhood, Perinatal Cortical Maturation, and Risk of Psychopathology in Children: The Mediating Role of Pregnancy Complications.Biological psychiatry global open science · 2026Article
- Prenatal and early-life determinants of neurodevelopment: A decade of discoveries and new directions in ABCD.Developmental cognitive neuroscience · 2026Review
- Evaluation of a New Paracingulate Sulcus Identification and Measurement Protocol.Human brain mapping · 2026Article
- Genetic insights on the mechanisms of human cortical folding.bioRxiv : the preprint server for biology · 2026Article
- Reassessing Asymmetry Reduction in Psychosis: Cingulate Folding and Gyrification Covariance in Patients with Auditory Hallucinations.Schizophrenia bulletin · 2026Article
- Brain Folding Trajectories in Amyotrophic Lateral Sclerosis.Human brain mapping · 2026Article
- Sulcal Widening in Schizophrenia Maps onto Sulcal Hubs and Energy-Synaptic Genes.bioRxiv : the preprint server for biology · 2026Article
- Music participation, global cortical morphometry, and later language outcomes in the ABCD study.Frontiers in psychology · 2026Article
- Sulcal depth-based individualized structural covariance networks reveal multi-level brain reorganization associated with cognitive performance in COPD.Frontiers in neuroscience · 2026Article
- Heritability of gray matter volume and asymmetry in chimpanzees (Pan troglodytes) and their association to cognitive abilities and tool use.Brain structure & function · 2025Article
- Socioeconomic context influences the heritability of child cortical structure.Communications biology · 2025Article
- Socioeconomic context influences the heritability of child cortical structure.medRxiv : the preprint server for health sciences · 2025Article
- Genetic foundations of interindividual neurophysiological variability.Science advances · 2025Article
- Genetic Foundations of Inter-individual Neurophysiological Variability.bioRxiv : the preprint server for biology · 2025Article
- Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia.Developmental cognitive neuroscience · 2025Article
- Longitudinal Changes of Quantitative Brain Tissue Properties Induced by Balance Training.Human brain mapping · 2025Article
- Article
- Cortical Morphological Networks Differ Between Gyri and Sulci.Neuroscience bulletin · 2025Article
- Spurious correlations in surface-based functional brain imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
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18 authors.
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Abstract
Cortical folds help drive the parcellation of the human cortex into functionally specific regions. Variations in the length, depth, width, and surface area of these sulcal landmarks have been associated with disease, and may be genetically mediated. Before estimating the heritability of sulcal variation, the extent to which these metrics can be reliably extracted from in-vivo MRI must be established. Using four independent test-retest datasets, we found high reliability across the brain (intraclass correlation interquartile range: 0.65-0.85). Heritability estimates were derived for three family-based cohorts using variance components analysis and pooled (total N > 3000); the overall sulcal heritability pattern was correlated to that derived for a large population cohort (N > 9000) calculated using genomic complex trait analysis. Overall, sulcal width was the most heritable metric, and earlier forming sulci showed higher heritability. The inter-hemispheric genetic correlations were high, yet select sulci showed incomplete pleiotropy, suggesting hemisphere-specific genetic influences.
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