ArticleScientific reports2020
Fine scale spatial investigation of multiple insecticide resistance and underlying target-site and metabolic mechanisms in Anopheles gambiae in central Côte d'Ivoire.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05736679 (EaveTubes for Control of Vector Borne Diseases in Côte d'Ivoire), which is not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
EaveTubes for Control of Vector Borne Diseases in Côte d'Ivoire
Who cites it
27 citing papers in PubMed.
- Characteristics of malaria vector populations and transmission before a randomised controlled trial assessing the efficacy of next-generation insecticide-treated nets in Côte d'Ivoire.Parasites & vectors · 2025Trial
- Trial
- Trial
- Entomological indicators of malaria transmission prior to a cluster-randomized controlled trial of a 'lethal house lure' intervention in central Côte d'Ivoire.Malaria journal · 2022Trial
- Integrating Community Practices, Vector Resistance, and Molecular Xenomonitoring of Wuchereria Bancrofti: A One Health Implementation Study in Lymphatic Filariasis-Endemic Communities.Acta parasitologica · 2026Article
- Mechanisms of carbamate resistance in the malaria vector:Parasite epidemiology and control · 2026Review
- Anopheles coluzzii from Sakassou, Central Côte d'Ivoire show aggravated resistance to pyrethroids and organophosphate but are fully susceptible to clothianidin.Parasites & vectors · 2026Article
- Disparities in long-lasting insecticidal bed net usage and malaria burden 2 years after a mass distribution campaign in central Côte d'Ivoire: A cross-sectional survey prior to a cluster randomised trial.PLOS global public health · 2026Article
- Insecticide-treated screening of windows for household protection against insecticide-resistant Anopheles gambiae sensu lato in Côte d'Ivoire: a semi-field trial.Parasites & vectors · 2025Article
- Managing insecticide resistance in malaria vectors in Africa: case studies from Cameroon, Côte d'Ivoire and Tanzania.Malaria journal · 2025Article
- Transcriptome and Functional Analyses Revealed the Carboxylesterase Genes Involved in Pyrethroid Resistance inInsects · 2025Article
- Ecological drivers of malaria vector habitat and transmission over 1 year of long-lasting insecticidal net intervention in Côte d'Ivoire.Parasites & vectors · 2025Article
- Insecticide resistance and species diversity in Anopheles gambiae s.l. in Côte d'Ivoire.PloS one · 2025Article
- Measuring insecticide resistance in a vacuum: exploring next steps to link resistance data with mosquito control efficacy.Journal of medical entomology · 2024Review
- The impact of agrochemical pollutant mixtures on the selection of insecticide resistance in the malaria vector Anopheles gambiae: insights from experimental evolution and transcriptomics.Malaria journal · 2024Article
- Article
- Efficacy of a 'lethal house lure' against Culex quinquefasciatus from Bouaké city, Côte d'Ivoire.Parasites & vectors · 2023Article
- Relationship between insecticide resistance profiles in Anopheles gambiae sensu lato and agricultural practices in Côte d'Ivoire.Parasites & vectors · 2023Article
- Escalating pyrethroid resistance in two major malaria vectors Anopheles funestus and Anopheles gambiae (s.l.) in Atatam, Southern Ghana.BMC infectious diseases · 2022Article
- Evolution of thePathogens (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Routine monitoring of occurrence, levels and mechanisms of insecticide resistance informs effective management strategies, and should be used to assess the effect of new tools on resistance. As part of a cluster randomised controlled trial evaluating a novel insecticide-based intervention in central Côte d'Ivoire, we assessed resistance and its underlying mechanisms in Anopheles gambiae populations from a subset of trial villages. Resistance to multiple insecticides in An. gambiae s.s. and An. coluzzii was detected across villages, with dose-response assays demonstrating extremely high resistance intensity to the pyrethroid deltamethrin (> 1,500-fold), and mortality following exposure to pyrethroid-treated bednets was low (< 30% mortality in cone bioassays). The 1014F kdr mutation was almost fixed (≥ 90%) in all villages but the 1575Y kdr-amplifying mutation was relatively rare (< 15%). The carbamate and organophosphate resistance-associated Ace-1 G119S mutation was also detected at moderate frequencies (22-43%). Transcriptome analysis identified overexpression of P450 genes known to confer pyrethroid resistance (Cyp9K1, Cyp6P3, and Cyp6M2), and also a carboxylesterase (COEAE1F) as major candidates. Cyp6P3 expression was high but variable (up to 33-fold) and correlated positively with deltamethrin resistance intensity across villages (r
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.