ArticleScientific data2020
A high-resolution in vivo magnetic resonance imaging atlas of the human hypothalamic region.
Article in Scientific data, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.
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Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Deep brain stimulation of the hypothalamic region: a systematic review.Acta neurochirurgica · 2025Pooled it
- Deep Brain Stimulation of the Habenula: Systematic Review of the Literature and Clinical Trial Registries.Frontiers in psychiatry · 2021Pooled it
- Brain and physiological responses to flavored waters with different sweeteners: a randomized crossover study in healthy young adults.The American journal of clinical nutrition · 2026Trial
- Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights.Nature metabolism · 2025Trial
- Mapping autonomic, mood and cognitive effects of hypothalamic region deep brain stimulation.Brain : a journal of neurology · 2021Trial
- Autonomic Network Signatures of Interictal Cardiorespiratory Dysfunction in Patients With Temporal Lobe Epilepsy.Neurology · 2026Article
- Substantial evidence against sex differences in bed nucleus of the stria terminalis volume in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Neuropsychological and metabolic interconnectivity in obesity, anorexia and bulimia nervosa - an integrative literature review.Metabolic brain disease · 2026Review
- Supratentorial Brain Lesions in Unconscious Patients Map to a Common Human Brain Circuit.Annals of neurology · 2026Observational
- Neural basis of successful DBS for OCD after failed capsulotomy.medRxiv : the preprint server for health sciences · 2026Article
- Hypothalamic insulin resistance in type 2 diabetes is localized to the posterior hypothalamus.JCI insight · 2026Article
- Morphological and anatomical variations in subcortical anatomy between humans and chimpanzees associated with heritability patterns related to human behavioral traits.Communications biology · 2026Article
- Pallidal alpha activity is an electrophysiological biomarker of symptom severity in obsessive-compulsive disorder.Research square · 2026Article
- The Effect of Caffeine Consumption and Acute Withdrawal on Resting-State fMRI Brain Connectivity, Mood and Cognition.The European journal of neuroscience · 2026Article
- Hinoki Cypress Aroma Facilitates Swallowing via Premotor and Hypothalamic Down-modulation: A Randomized Within-subject Crossover fMRI Study.Dysphagia · 2026Article
- Exploring the Role of Skull Base Anatomy in Surgical Approach Selection and Endocrinological Outcomes in Craniopharyngiomas.Journal of clinical medicine · 2026Article
- A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Disinhibited behavior associated with rapid clinical response to deep brain stimulation for obsessive-compulsive disorder: illustrative cases.Journal of neurosurgery. Case lessons · 2025Article
- A human brain network linked to restoration of consciousness after deep brain stimulation.Nature communications · 2025Article
- A cross-species analysis of neuroanatomical covariance sex differences in humans and mice.Biology of sex differences · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The study of the hypothalamus and its topological changes provides valuable insights into underlying physiological and pathological processes. Owing to technological limitations, however, in vivo atlases detailing hypothalamic anatomy are currently lacking in the literature. In this work we aim to overcome this shortcoming by generating a high-resolution in vivo anatomical atlas of the human hypothalamic region. A minimum deformation averaging (MDA) pipeline was employed to produce a normalized, high-resolution template from multimodal magnetic resonance imaging (MRI) datasets. This template was used to delineate hypothalamic (n = 13) and extrahypothalamic (n = 12) gray and white matter structures. The reliability of the atlas was evaluated as a measure for voxel-wise volume overlap among raters. Clinical application was demonstrated by superimposing the atlas into datasets of patients diagnosed with a hypothalamic lesion (n = 1) or undergoing hypothalamic (n = 1) and forniceal (n = 1) deep brain stimulation (DBS). The present template serves as a substrate for segmentation of brain structures, specifically those featuring low contrast. Conversely, the segmented hypothalamic atlas may inform DBS programming procedures and may be employed in volumetric studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.