ArticleNature communications2020
Entamoeba and Giardia parasites implicated as hosts of CRESS viruses.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 51 citations in OpenAlex.
- Identification of a novel toti-like virus symbiotic with Giardia duodenalis.Archives of virology · 2026Article
- Anionic Liposomes as Optimal Membrane Fusion Carriers Enabling in Situ Multiplexed Detection of Extracellular Vesicle MicroRNAs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Resolving the Phylogenetic Placement of the FSfaCV/PCV5-Related Viruses Within the Genus Macochavirus.Transboundary and emerging diseases · 2026Article
- Identification and characterization of novel CRESS-DNA viruses in the human respiratory tract.Virology journal · 2025Article
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- Viruses of parasites: A roadmap toward diagnostic and therapeutic development.PLoS neglected tropical diseases · 2025Review
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- Viral metagenomic analysis of fecal samples fromFrontiers in cellular and infection microbiology · 2025Article
- 2024 taxonomic update for the families Naryaviridae, Nenyaviridae, and Vilyaviridae.Archives of virology · 2024Article
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- 2024 taxonomy update for the family Circoviridae.Archives of virology · 2024Review
- Microbial Matryoshka: Addressing the Relationship between Pathogenic Flagellated Protozoans and Their RNA Viral Endosymbionts (FamilyVeterinary sciences · 2024Review
- Diverse Circular DNA Viral Communities in Blood, Oral, and Fecal Samples of Captive Lemurs.Viruses · 2024Article
- Dental complications as a potential indicator of Redondovirus infection: a cross-sectional study.BMC infectious diseases · 2024Article
- Genomoviruses in Liver Samples ofMicroorganisms · 2024Article
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- The oral microbiome: diversity, biogeography and human health.Nature reviews. Microbiology · 2024Review
- Diverse Small Circular DNA Viruses Identified in an American Wigeon Fecal Sample.Microorganisms · 2024Article
- Review
- Detection and genetic characterization of circoviruses in more than 80 bat species from eight countries on four continents.Veterinary research communications · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metagenomic techniques have enabled genome sequencing of unknown viruses without isolation in cell culture, but information on the virus host is often lacking, preventing viral characterisation. High-throughput methods capable of identifying virus hosts based on genomic data alone would aid evaluation of their medical or biological relevance. Here, we address this by linking metagenomic discovery of three virus families in human stool samples with determination of probable hosts. Recombination between viruses provides evidence of a shared host, in which genetic exchange occurs. We utilise networks of viral recombination to delimit virus-host clusters, which are then anchored to specific hosts using (1) statistical association to a host organism in clinical samples, (2) endogenous viral elements in host genomes, and (3) evidence of host small RNA responses to these elements. This analysis suggests two CRESS virus families (Naryaviridae and Nenyaviridae) infect Entamoeba parasites, while a third (Vilyaviridae) infects Giardia duodenalis. The trio supplements five CRESS virus families already known to infect eukaryotes, extending the CRESS virus host range to protozoa. Phylogenetic analysis implies CRESS viruses infecting multicellular life have evolved independently on at least three occasions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.