Trial reportJournal of neurointerventional surgery2021
Clinical trial of carotid artery stenting using dual-layer CASPER stent for carotid endarterectomy in patients at high and normal risk in the Japanese population.
Trial report in Journal of neurointerventional surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Incidence, Timing and Associated Factors of In-Stent Restenosis after CASPER Placement: A Single-Center Retrospective Study.Journal of neuroendovascular therapy · 2026Article
- Direct carotid stenting with minimal predilation after embolic protection device crossing failure in cervical internal carotid artery dissection: A case report.Surgical neurology international · 2026Article
- Probable Delayed Plaque Protrusion After Carotid Artery Stenting With a Dual-Layer Micromesh Stent.JACC. Case reports · 2025Article
- Management of complex symptomatic renal artery aneurysm in a patient with Sjögren's syndrome and systemic lupus erythematosus.BMJ case reports · 2025Article
- A case of de novo extra-stent ulceration induced by persistent plaque protrusion after carotid artery stenting with a CASPER stent for a large-volume unstable plaque.Radiology case reports · 2024Article
- Current Status of Carotid Artery Stenting.Interventional radiology (Higashimatsuyama-shi (Japan) · 2024Review
- Intraprocedural and Delayed Plaque Protrusion in Carotid Artery Stenting Using a Dual-Layer Metallic Stent.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- Important Notes for Preventing Entrapment of Distal Filter-based Embolic Protection Device in Carotid Artery Stenting.Neurologia medico-chirurgica · 2024Article
- Clinical results of 30 consecutive patients of carotid artery stenosis treated with CASPER stent placement: 1-year follow-up and in-stent findings on intravascular ultrasound examination immediately and 6 months after treatment.Journal of neurointerventional surgery · 2024Article
- Subacute In-Stent Occlusion 2 Weeks after CASPER Rx Stenting: A Case Report.Journal of neuroendovascular therapy · 2023Article
- Intraprocedural Plaque Protrusion during Carotid Artery Stenting with a CASPER Stent: A Case Report.Journal of neuroendovascular therapy · 2023Article
- Carotid Artery Stenting Using Stent-in-Stent Technique with a Closed-Cell Stent and a Dual-Layer Micromesh Stent: A Case Report.Journal of neuroendovascular therapy · 2023Article
- The case of treatment for carotid web - Double-layer micromesh stent implantation in our hospital.Surgical neurology international · 2023Article
- The endothelialization on carotid web treated with dual layer stent placement: a case report.Radiology case reports · 2022Article
- Comparison of Restenosis Risk in Single-Layer versus Dual-Layer Carotid Stents: A Duplex Ultrasound Evaluation.Cardiovascular and interventional radiology · 2022Article
- Clinical Outcomes of Second- versus First-Generation Carotid Stents: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Efficacy of Post-Dilatation during Carotid Artery Stenting for Unstable Plaque Using a Double-Layer Stent Evaluated by OFDI.Journal of neuroendovascular therapy · 2022Article
- A Case of Intraprocedural Plaque Protrusion during Carotid Artery Stenting Using the Stent-in-Stent Technique for Carotid Artery Stenosis with Unstable Plaque.Journal of neuroendovascular therapy · 2022Article
- Diabetes Mellitus and Clinical Outcomes in Carotid Artery Revascularization Using Second-Generation, MicroNet-Covered Stents: Analysis from the PARADIGM Study.Journal of diabetes research · 2022Article
Corrections and comments
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Authors and funding
19 authors at 18 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe dual-layer nitinol CASPER stent was designed to prevent plaque prolapse into its strut and periprocedural stroke.
objectiveTo conduct a clinical trial for government approval of the device in patients at either high or normal risk for carotid endarterectomy (CEA).
methodsEligible patients had ≥50% symptomatic stenosis or ≥80% asymptomatic stenosis according to the North American Symptomatic Carotid Endarterectomy Trial methods (peak systolic velocity 130 and 230 cm/s on ultrasonography, respectively). The primary endpoint was the lack of major adverse events (MAEs), defined as death, stroke, and myocardial infarction within 30 days, and ipsilateral stroke within 1 year. The performance goal was set at 90.5%. MAE rates were also compared between the CEA high- and normal-risk groups.
results140 carotid artery stenting procedures, including 40% of patients at high risk and 60% at normal risk for CEA, were performed in 13 institutes. MAEs occurred in two cases (one intraprocedural and one postprocedural stroke), and the MAE rate was 1.4%. The non-MAE rate was 98.6% according to Kaplan-Meier analysis, which was superior to the previously set performance goal. The deployment success, target lesion revascularization (TLR), in-stent restenosis, and cerebrovascular event rates were 99.3%, 2.4%, 8.5%, and 7.2%, respectively. The MAE rate in patients with normal CEA risk was 1.2%, which was similar to the high-risk CEA group, with no significant difference due to the small number of MAEs.
conclusionsThe MAE rate following use of the CASPER stent was low (1.4%). The MAE, deployment success, TLR, in-stenosis, and cerebrovascular event rates were similar to those of previous reports.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.