Evidence map›Paper›PMID 32934117›Full record

ArticlemSystems2020

Gut Microbiota and Metabolome Alterations Associated with Parkinson's Disease.

Sarah Vascellari, Vanessa Palmas, Marta Melis, Silvia Pisanu, Roberto Cusano, Paolo Uva, Daniela Perra, Veronica Madau, Marianna Sarchioto, Valentina Oppo and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 6 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 6 syntheses or guidelines pooled it, 280 citations in OpenAlex.

  1. Pooled it
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  6. Pooled it
  7. Trial
  8. Article
  9. Article
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  11. Review
  12. Article
  13. Branched-chain amino acids ameliorate CD4NPJ Parkinson's disease · 2026
    Article
  14. Nutrients · 2026
    Article
  15. Article
  16. Dietary Yam (Nutrients · 2026
    Article
  17. Article
  18. Review
  19. Review
  20. Article

119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Sarah VascellariDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Cagliari, Cagliari, Italy.
Vanessa PalmasDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Cagliari, Cagliari, Italy.
Marta MelisNeurology Service and Stroke Unit, AO Brotzu Hospital, Cagliari, Italy.
Silvia PisanuDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Cagliari, Cagliari, Italy.
Roberto CusanoCRS4, Science and Technology Park Polaris, Piscina Manna, Pula, Cagliari, Italy.
Paolo UvaCRS4, Science and Technology Park Polaris, Piscina Manna, Pula, Cagliari, Italy.
Daniela PerraDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Cagliari, Cagliari, Italy.
Veronica MadauDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Cagliari, Cagliari, Italy.
Marianna SarchiotoNeurology Service and Stroke Unit, AO Brotzu Hospital, Cagliari, Italy.
Valentina OppoNeurology Service and Stroke Unit, AO Brotzu Hospital, Cagliari, Italy.
Nicola SimolaDepartment of Biomedical Sciences, Section of Neuropsychopharmacology, University of Cagliari, Cagliari, Italy.
Micaela MorelliDepartment of Biomedical Sciences, Section of Neuropsychopharmacology, University of Cagliari, Cagliari, Italy.
Maria Laura SantoruDepartment of Biomedical Sciences, Oncology and Molecular Pathology Unit, University of Cagliari, Cagliari, Italy.
Luigi AtzoriDepartment of Biomedical Sciences, Oncology and Molecular Pathology Unit, University of Cagliari, Cagliari, Italy.
Maurizio MelisNeurology Service and Stroke Unit, AO Brotzu Hospital, Cagliari, Italy.
Giovanni CossuNeurology Service and Stroke Unit, AO Brotzu Hospital, Cagliari, Italy.
Aldo ManzinDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Cagliari, Cagliari, Italy aldomanzin@medicina.unica.it.ORCID https://orcid.org/0000-0003-2961-3428
University of Cagliari · ITAzienda Ospedaliera G. Brotzu · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease is a neurodegenerative disorder characterized by the accumulation of intracellular aggregates of misfolded alpha-synuclein along the cerebral axis. Several studies report the association between intestinal dysbiosis and Parkinson's disease, although a cause-effect relationship remains to be established. Herein, the gut microbiota composition of 64 Italian patients with Parkinson's disease and 51 controls was determined using a next-generation sequencing approach. A real metagenomics shape based on gas chromatography-mass spectrometry was also investigated. The most significant changes within the Parkinson's disease group highlighted a reduction in bacterial taxa, which are linked to anti-inflammatory/neuroprotective effects, particularly in the

Indexed as

16S RNAgut microbiotametabolomePD

Identifiers

PMID32934117
PMCPMC7498685
OpenAlexW3085634769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.