ArticleLearning & memory (Cold Spring Harbor, N.Y.)2020
Prefrontal cortical and nucleus accumbens contributions to discriminative conditioned suppression of reward-seeking.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- The Theoretical Evolution of Social Memory and the Core Contribution of the Medial Prefrontal Cortex.Neuroscience bulletin · 2026Review
- Top-down corticostriatal control of adaptive restraint during motivational conflict.Science advances · 2026Article
- Sexually dimorphic effects of single prolonged stress on conditioned suppression behavior in Long Evans rats with no detection of altered mRNA expression of VGLUT1, GAD1, and Arc in the ventral hippocampus.Frontiers in behavioral neuroscience · 2026Article
- Prefrontal cortex development and its implications in mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Toward a Genetic Signature of Resistance to Activity-Based Anorexia in Striatal Projecting Cortical Neurons.The International journal of eating disorders · 2025Article
- Assessing the role of BNST GABA neurons in backward conditioned suppression.Neurobiology of learning and memory · 2025Article
- The role of the prefrontal cortex in cocaine-induced noradrenaline release in the nucleus accumbens: a computational study.Biological cybernetics · 2025Article
- Sex-biased neural encoding of threat discrimination in nucleus accumbens afferents drives suppression of reward behavior.Nature neuroscience · 2024Article
- Orbitofrontal cortex to dorsal striatum circuit is critical for incubation of oxycodone craving after forced abstinence.Addiction biology · 2024Article
- Brain-Wide Projections and Differential Encoding of Prefrontal Neuronal Classes Underlying Learned and Innate Threat Avoidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Sex and age differences in cognitive bias and neural activation in response to cognitive bias testing.Neurobiology of stress · 2022Article
- Distinct Medial Orbitofrontal-Striatal Circuits Support Dissociable Component Processes of Risk/Reward Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Threat and Bidirectional Valence Signaling in the Nucleus Accumbens Core.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Prefrontal-hippocampal interactions supporting the extinction of emotional memories: the retrieval stopping model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex.eLife · 2021Article
- Dissociable roles of the nucleus accumbens core and shell subregions in the expression and extinction of conditioned fear.Neurobiology of stress · 2021Article
- Learning is a matter of history and relevance for lateral hypothalamus.Nature neuroscience · 2021Article
- Ventral pallidum neurons dynamically signal relative threat.Communications biology · 2021Article
- Characterizing Different Strategies for Resolving Approach-Avoidance Conflict.Frontiers in neuroscience · 2021Article
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fear can potently inhibit ongoing behavior, including reward-seeking, yet the neural circuits that underlie such suppression remain to be clarified. Prior studies have demonstrated that distinct subregions of the rodent medial prefrontal cortex (mPFC) differentially affect fear behavior, whereby fear expression is promoted by the more dorsal prelimbic cortex (PL) and inhibited by the more ventral infralimbic cortex (IL). These mPFC regions project to subregions of the nucleus accumbens, the core (NAcC) and shell (NAcS), that differentially contribute to reward-seeking as well as affective processes that may be relevant to fear expression. Here, we investigated how these mPFC and NAc subregions contribute to discriminative fear conditioning, assessed by conditioned suppression of reward-seeking. Bilateral inactivation of the NAcS or PL reduced the expression of conditioned suppression to a shock-associated CS+, whereas NAcC inactivation reduced reward-seeking without affecting suppression. IL inactivation caused a general reduction in conditioned suppression following discriminative conditioning, but not when using a single-stimulus design. Pharmacological disconnection of the PL → NAcS pathway revealed that this projection mediates conditioned suppression. These data add to a growing literature implicating discrete cortico-striatal pathways in the suppression of reward-seeking in response to aversive stimuli. Dysfunction within related structures may contribute to aberrant patterns of behavior in psychiatric illnesses including substance use disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.