Evidence map›Paper›PMID 32934084›Full record

ArticlemBio2020

A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat.

James H Morrison, Caitlin Miller, Laura Bankers, Gary Crameri, Lin-Fa Wang, Eric M Poeschla

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Antiviral effects of interferon-stimulated genes in bats.Frontiers in cellular and infection microbiology · 2023
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Bats in ecosystems and their Wide spectrum of viral infectious potential threats: SARS-CoV-2 and other emerging viruses.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

James H MorrisonDivision of Infectious Diseases, University of Colorado, Aurora, Colorado, USA.
Caitlin MillerDivision of Infectious Diseases, University of Colorado, Aurora, Colorado, USA.
Laura BankersDivision of Infectious Diseases, University of Colorado, Aurora, Colorado, USA.
Gary CrameriCSIRO Australian Animal Health Laboratory, Geelong, Australia.
Lin-Fa WangProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.ORCID 0000-0003-2752-0535
Eric M PoeschlaDivision of Infectious Diseases, University of Colorado, Aurora, Colorado, USA eric.poeschla@cuanschutz.edu.ORCID 0000-0003-1598-5415
University of Colorado Anschutz Medical Campus · USCommonwealth Scientific and Industrial Research Organisation · AUDuke-NUS Medical School · SG

Funding

LEDGF/p7 and HIV IntegrationR01AI077344 · NIAID · UNIVERSITY OF COLORADO DENVER · PI POESCHLA, ERIC M. · 2008 to 2018
$4.1M
Novel Approaches to Innate Immunity Against HIV-1 and Other Co-infection VirusesDP1DA043915 · NIDA · UNIVERSITY OF COLORADO DENVER · PI POESCHLA, ERIC M. · 2017 to 2021
$3.9M
NIAID NIH HHS R01 AI077344NIDA NIH HHS DP1 DA043915
6 · The paper itself

Abstract

Bats are primary reservoirs for multiple lethal human viruses, such as Ebola, Nipah, Hendra, rabies, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV), and, most recently, SARS-CoV-2. The innate immune systems of these immensely abundant, anciently diverged mammals remain insufficiently characterized. While bat genomes contain many endogenous retroviral elements indicative of past exogenous infections, little is known about restrictions to extant retroviruses. Here, we describe a major postentry restriction in cells of the yinpterochiropteran bat

Indexed as

3T3 CellsAnimalsAotidaeCatsCell LineChiropteraCyclophilin AFerretsGammaretrovirusHEK293 CellsHumansImmunity, InnateLentiviruses, PrimateMiceRNA InterferenceRNA, Small InterferingCyclophilin ARNA, Small InterferingTripartite Motif Proteinsbatscyclophilin AHIV-1lentivirusMegachiropteraMX2Pteropus alectorestriction factorrestriction factorsretrovirusYinpterchiroptera

Identifiers

PMID32934084
PMCPMC7492736
OpenAlexW3084483640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.