Evidence map›Paper›PMID 32934021›Full record

ArticleCancer research2020

Breast Cancer Cell Detection and Characterization from Breast Milk-Derived Cells.

Poornima Bhat-Nakshatri, Brijesh Kumar, Ed Simpson, Kandice K Ludwig, Mary L Cox, Hongyu Gao, Yunlong Liu, Harikrishna Nakshatri

Open access · greenAbstract read
In one paragraph

Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Transporters and drug secretion into human breast milk.Expert opinion on drug metabolism & toxicology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Poornima Bhat-NakshatriDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Brijesh KumarDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Ed SimpsonDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
Kandice K LudwigDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Mary L CoxIU Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana.
Hongyu GaoDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
Yunlong LiuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
Harikrishna NakshatriDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana. hnakshat@iupui.edu.ORCID 0000-0001-8876-0052
Indiana University School of MedicineIndiana University Health · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
NCI NIH HHS P30 CA082709
6 · The paper itself

Abstract

Radiologic techniques remain the main method for early detection for breast cancer and are critical to achieve a favorable outcome from cancer. However, more sensitive detection methods to complement radiologic techniques are needed to enhance early detection and treatment strategies. Using our recently established culturing method that allows propagation of normal and cancerous breast epithelial cells of luminal origin, flow cytometry characterization, and genomic sequencing, we show that cancer cells can be detected in breast milk. Cells derived from milk from the breast with cancer were enriched for CD49f

Indexed as

Breast NeoplasmsCarcinoma, Ductal, BreastCell Culture TechniquesFemaleHumansMilk, HumanNeoplastic Stem Cells

Identifiers

PMID32934021
PMCPMC7642166
OpenAlexW3087136760

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.