Evidence map›Paper›PMID 32934009›Full record

ArticleThe Journal of biological chemistry2020

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from

Tongri Liu, Martine I Abboud, Rasheduzzaman Chowdhury, Anthony Tumber, Adam P Hardy, Kerstin Lippl, Christopher T Lohans, Elisabete Pires, James Wickens, Michael A McDonough and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Gas Tunnel Engineering of Prolyl Hydroxylase Reprograms Hypoxia Signaling in Cells.Angewandte Chemie (International ed. in English) · 2024
    Article
  5. Article
  6. mSphere · 2024
    Article
  7. Article
  8. bioRxiv : the preprint server for biology · 2023
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Tongri LiuChemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.
Martine I AbboudChemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.
Rasheduzzaman ChowdhuryChemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.
Anthony TumberChemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.
Adam P HardyChemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.
Kerstin LipplChemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.
Christopher T LohansChemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.
Elisabete PiresChemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.
James WickensChemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.
Michael A McDonoughChemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.
Christopher M WestDepartment of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Christopher J SchofieldChemistry Research Laboratory, University of Oxford, Oxford, United Kingdom. Electronic address: christopher.schofield@chem.ox.ac.uk.
University of Oxford · GBUniversity of Georgia · US

Funding

Glycoregulation of Skp1 in the cytoplasm and nucleusR01GM084383 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI BLADER, IRA J, WEST, CHRISTOPHER M. · 2009 to 2018
$2.9M
Biotechnology and Biological Sciences Research CouncilCancer Research UKNIGMS NIH HHS R01 GM084383Wellcome Trust
6 · The paper itself

Abstract

In animals, the response to chronic hypoxia is mediated by prolyl hydroxylases (PHDs) that regulate the levels of hypoxia-inducible transcription factor α (HIFα). PHD homologues exist in other types of eukaryotes and prokaryotes where they act on non HIF substrates. To gain insight into the factors underlying different PHD substrates and properties, we carried out biochemical and biophysical studies on PHD homologues from the cellular slime mold,

Indexed as

Amino Acid SequenceAnimalsBinding SitesBiocatalysisCrystallography, X-RayDictyosteliumHumansHydroxylationHypoxia-Inducible Factor 1, alpha SubunitKineticsMolecular Dynamics SimulationOxygenProlyl HydroxylasesProtein Structure, TertiaryProtozoan ProteinsRecombinant ProteinsHypoxia-Inducible Factor 1, alpha SubunitOxygenProlyl HydroxylasesProtozoan ProteinsRecombinant ProteinsS-Phase Kinase-Associated Proteins2-oxoglutarate/α-ketoglutarate oxygenaseDictyostelium discoideumdioxygenasehypoxiahypoxia-inducible factor (HIF)hypoxia/oxygen sensorprolyl-hydroxylaseprotein evolutionS-phase kinase-associated protein 1 (Skp1)Toxoplasma gondii

Identifiers

PMID32934009
PMCPMC7864055
OpenAlexW3087139263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.