ReviewCanadian family physician Medecin de famille canadien2020
Update on the adverse effects of antimicrobial therapies in community practice.
Review in Canadian family physician Medecin de famille canadien, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Adverse effects of the PENTO(CLO) protocol in the prevention and management of iatrogenic head and neck bone necrosis in cancer patients: A systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Topical versus systemic antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Systemic antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Swedish national guidelines for diagnosis and management of acute appendicitis in adults and children.BJS open · 2025Guideline
- Assessing the long-term effects of microbial therapeutics as treatment within psychiatry: a systematic review.Frontiers in psychiatry · 2025Pooled it
- A Review of the Association between Infections, Seizures, and Drugs.Central nervous system agents in medicinal chemistry · 2025Pooled it
- Biological Mechanisms of Polyphenols againstInfectious disorders drug targets · 2025Pooled it
- Antibiotic treatment to prevent pediatric acute otitis media infectious complications: A meta-analysis.PloS one · 2024Pooled it
- Patient-Reported Outcomes Following Systemic Antibiotic Adjunct to Nonsurgical Treatment of Periodontitis: A Randomized Controlled Clinical Trial.Clinical and experimental dental research · 2025Trial
- Localised 0.2% chlorhexidine irrigation delivery system versus oral antibiotics in reducing postoperative complications in the surgical extraction of impacted mandibular third molar (IMTM). - a randomised controlled trial.Medicina oral, patologia oral y cirugia bucal · 2024Trial
- Safety of routine antimicrobial prophylaxis for surgery (SAPPHIRE): a prospective multi-centre cohort study.EClinicalMedicine · 2026Article
- Intravesically administered human defensin-5 ameliorates E. coli induced catheter associated-urinary tract infections in female SD rats.Archives of microbiology · 2026Article
- Oral antibiotics prescribing patterns and associated diarrhea risk: Public health implications.Journal of public health research · 2026Article
- Evolving prokinetic therapy: New targets and therapeutic opportunities in gastrointestinal motility disorders.World journal of gastrointestinal pharmacology and therapeutics · 2026Review
- Management of acute dental pain in adults.Canadian family physician Medecin de famille canadien · 2026Article
- Clinical and genomic characteristics of hypervirulent Klebsiella pneumoniae isolated from throat culture suggesting an emerging causative agent of pharyngitis.BMC infectious diseases · 2026Article
- Article
- Parental awareness and management of antibiotic side effects and allergies in children and young people: a UK survey.JAC-antimicrobial resistance · 2026Article
- Implementation of a Pharmacist-Led Penicillin Allergy Interview at a Veterans Care Facility.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2026Article
- Research Landscape and Emerging Trends in Herbal Medicine for Pediatric Respiratory Tract Infections: A CiteSpace-Based Bibliometric Analysis.Health science reports · 2026Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo gather information about antibiotic side effects to be used as a reference and learning resource for prescribing physicians. QUALITY OF EVIDENCE: A search of websites of various independent national agencies and recent review articles was performed. A summary table of adverse effects for each group of antimicrobials was then created, identifying allergies, short-term harms, and serious harms. The occurrence rate of each was listed when available. MAIN MESSAGE: Antimicrobials are necessary to treat various diseases. However, they cause adverse effects, such as allergic reactions, in addition to increased bacterial resistance. There is increasing awareness of the need to detect and evaluate adverse effects associated with medicines. Recently, severe and serious harms have been described for commonly used antibiotics. Therefore, current knowledge of harms from systemic oral antibiotics that are regularly used in family medicine is summarized in this article.
conclusionIt is difficult to identify and ascribe exact probabilities of most harms. However, all common antimicrobials create harms that must be considered when choosing whether to prescribe. Many adverse effects go unrecognized by prescribers. As side effects are inevitable, antimicrobials must be prescribed for as short a course as possible, only when the probability of benefit is greater than the risk of harm.
Indexed as
Identifiers
32933978PMC7491661What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.