Evidence map›Paper›PMID 32933597›Full record

ArticleDevelopment and psychopathology2020

Shared and distinct developmental pathways to ASD and ADHD phenotypes among infants at familial risk.

Meghan Miller, Shane Austin, Ana-Maria Iosif, Leiana de la Paz, Annie Chuang, Burt Hatch, Sally Ozonoff

Open access · greenAbstract read
In one paragraph

Article in Development and psychopathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Identification of Early Temperament Profiles in Infants at Elevated Likelihood for Autism and Attention-Deficit/Hyperactivity Disorder.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
  2. Sleep in Young Children With Autism, ADHD and Combined Presentations.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  3. Patterns of Early Development in Children with ADHD.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2026
    Article
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  6. Review
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  8. Trajectory research in children with an autism diagnosis: A scoping review.Autism : the international journal of research and practice · 2024
    Article
  9. Article
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  12. Review
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  15. Delay of Gratification in Preschoolers with Autism and Concerns for ADHD.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Article
  16. Future Directions for Infant Identification and Intervention for Autism Spectrum Disorder from a Transdiagnostic Perspective.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Meghan MillerDepartment of Psychiatry & Behavioral Sciences and MIND Institute, University of California, Davis, CA, USA.
Shane AustinGraduate Group in Biostatistics, University of California, Davis, CA, USA.
Ana-Maria IosifDepartment of Public Health Sciences, University of California, Davis, CA, USA.
Leiana de la PazDepartment of Psychiatry & Behavioral Sciences and MIND Institute, University of California, Davis, CA, USA.
Annie ChuangDepartment of Psychiatry & Behavioral Sciences and MIND Institute, University of California, Davis, CA, USA.
Burt HatchDepartment of Psychiatry & Behavioral Sciences and MIND Institute, University of California, Davis, CA, USA.
Sally OzonoffDepartment of Psychiatry & Behavioral Sciences and MIND Institute, University of California, Davis, CA, USA.
University of California, Davis · US

Funding

Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JUDY A. VAN DE WATER · 2020 to 2026
$9.7M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CRAWLEY, JACQUELINE N · 2013 to 2019
$8.5M
Infants at Risk of Autism: A Longitudinal StudyR01MH068398 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI OZONOFF, SALLY · 2003 to 2013
$6.1M
Development of a Prospective Video-Based Measure to Identify ASD Risk in InfancyR01MH099046 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI OZONOFF, SALLY · 2013 to 2016
$2.0M
Shared and Distinct Developmental Pathways to ADHD and Autism Spectrum DisorderR00MH106642 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MILLER, MEGHAN RHYS · 2017 to 2020
$863k
Shared and Distinct Developmental Pathways to ADHD and Autism Spectrum DisorderK99MH106642 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MILLER, MEGHAN RHYS · 2015 to 2016
$164k
NICHD NIH HHS P50 HD103526NICHD NIH HHS U54 HD079125NIMH NIH HHS K99 MH106642NIMH NIH HHS R00 MH106642NIMH NIH HHS R01 MH068398NIMH NIH HHS R01 MH099046
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are believed to share partially overlapping causal mechanisms suggesting that early risk markers may also overlap. Using latent profile analysis (LPA) in a sample of infants enriched for ASD and ADHD, we first examined the number of distinct groups of 3-year-old children, based on ADHD and ASD symptomatology. To investigate early predictors of ASD and ADHD symptom profiles, we next examined differences in trajectories of infant behaviors among the LPA classes spanning general development, negative affect, attention, activity level, impulsivity, and social behavior. Participants included 166 infants at familial risk for ASD (n = 89), ADHD (n = 38), or low-risk for both (n = 39) evaluated at 12, 18, 24, and 36 months of age. A three-class solution was selected reflecting a Typically Developing (TD) class (low symptoms; n = 108), an ADHD class (high ADHD/low ASD symptoms; n = 39), and an ASD class (high ASD/ADHD symptoms; n = 19). Trajectories of infant behaviors were generally suggestive of a gradient pattern of differences, with the greatest impairment within the ASD class followed by the ADHD class. These findings indicate a mixture of overlapping and distinct early markers of preschool ASD- and ADHD-like profiles that can be difficult to disentangle early in life.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderChild, PreschoolGenetic Predisposition to DiseaseHumansImpulsive BehaviorInfantPhenotypeADHDautismearly childhoodinfancylatent profile analysis

Identifiers

PMID32933597
PMCPMC7891894
OpenAlexW3087073100

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.