ArticleGenome biology2020
AuthentiCT: a model of ancient DNA damage to estimate the proportion of present-day DNA contamination.
Article in Genome biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- CHARON: estimating the drift time and the number of individuals in environmental DNA with diploid individuals.G3 (Bethesda, Md.) · 2026Article
- Article
- Investigating ancient human DNA preservation on cave walls and in rock art.Nature communications · 2026Article
- ChASM: a statistically rigorous method for the detection of chromosomal aneuploidies in ancient DNA studies.Bioinformatics (Oxford, England) · 2026Article
- Insights into human adaptation from ancient DNA.Nature genetics · 2026Review
- A high-coverage Neandertal genome from the Altai Mountains reveals population structure among Neandertals.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Archaeogenetics reconstructs demography and extreme parental consanguinity in a Bronze Age community from Southern Italy.Communications biology · 2025Article
- Comprehensive review of understanding ancient dietary habits using modern analytical techniques.Food chemistry. Molecular sciences · 2025Review
- Highly selective cannibalism in the Late Pleistocene of Northern Europe reveals Neandertals were targeted prey.Scientific reports · 2025Article
- CarpeDeam: a de novo metagenome assembler for heavily damaged ancient datasets.Genome biology · 2025Article
- Genomic insights from a final Bronze Age community buried in a collective tumulus in an Urnfield settlement in Northeastern Iberia.Communications biology · 2025Article
- Article
- Concerns about ancient DNA sequences reported from a Late Pleistocene individual from Southeast Asia.Current biology : CB · 2025Article
- Article
- Revisiting the Briggs Ancient DNA Damage Model: A Fast Maximum Likelihood Method to Estimate Post-Mortem Damage.Molecular ecology resources · 2025Article
- Forensic Microbiology: When, Where and How.Microorganisms · 2024Review
- Article
- Chronological and genetic analysis of an Upper Palaeolithic female infant burial from Borsuka Cave, Poland.iScience · 2023Article
- Review: Computational analysis of human skeletal remains in ancient DNA and forensic genetics.iScience · 2023Review
- decOM: similarity-based microbial source tracking of ancient oral samples using k-mer-based methods.Microbiome · 2023Article
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2 authors.
Funding
Abstract
Contamination from present-day DNA is a fundamental issue when studying ancient DNA from historical or archaeological material, and quantifying the amount of contamination is essential for downstream analyses. We present AuthentiCT, a command-line tool to estimate the proportion of present-day DNA contamination in ancient DNA datasets generated from single-stranded DNA libraries. The prediction is based solely on the patterns of post-mortem damage observed on ancient DNA sequences. The method has the power to quantify contamination from as few as 10,000 mapped sequences, making it particularly useful for analysing specimens that are poorly preserved or for which little data is available.
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